We collected 20 Malus domestica epigenomic datasets, including ChIP-seq, DNase-seq and DNA methylation datasets. A hidden Markov model was applied to aggregate or collapse the multi-dimensional matrices into a small number of chromatin states. We identified 24 chromatin states located in 620,122 segments across the whole genome, and different chromatin states contained different epigenetic features.
State | Preferential epigenetics marks | Preferential location |
---|---|---|
State 1 | weak accessible DNA | intergenic,promoter,TE |
State 2 | accessible DNA | promoter,intergenic |
State 3 | accessible DNA | promoter,intergenic |
State 4 | accessible DNA,H3K4me3,weak H3K27me3 | promoter,5'UTR,exon,intergenic |
State 5 | accessible DNA,H3K27me3,weak H3K4me3,weak H3K36me2 | intergenic,promoter |
State 6 | accessible DNA | intergenic,promoter |
State 7 | accessible DNA | intergenic,promoter |
State 8 | H3K36me2,accessible DNA | 3'UTR,exon,intergenic,promoter |
State 9 | H3K36me2 | intron,exon,3'UTR |
State 10 | weak H3K36me2 | intron |
State 11 | H3K4me3,H3K36me2,weak H3K27me3 | intron,exon |
State 12 | H3K4me3,weak H3K27me3,weak accessible DNA | intron |
State 13 | H3K4me3,H3K27me3,weak accessible DNA | exon |
State 14 | H3K4me3,H3K27me3,weak accessible DNA | exon |
State 15 | H3K27me3,weak H3K36me2,weak H3K4me3 | intron,exon |
State 16 | H3K27me3 | exon,intergenic,promoter,intron |
State 17 | H3K27me3,weak accessible DNA | intergenic,promoter,intron,exon |
State 18 | H3K27me3 | intergenic,TE,promoter |
State 19 | H3K27me3,accessible DNA | intergenic,promoter,TE |
State 20 | weak H3K27me3 | intergenic,TE,promoter |
State 21 | H3K27me3 | intergenic,TE |
State 22 | H3K27me3 | TE,intergenic |
State 23 | weak H3K27me3 | TE,intergenic |
State 24 | rare signal | intergenic,TE |