TissueCFM001116's detailed annotation
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Protein: Yellow color--query protein Green color--interaction proteins. Interaction line: Pink--proteins own interaction and positive co-expression relationship with target protein Blue--proteins own interaction and negative co-expression relationship with target protein Orange--proteins own interaction and protein-protein relationship with target protein |
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Module annotation (GSEA enrichment result)
| Function Annotation | FDR | Gene Ontolog |
|---|---|---|
| Homologous recombination | 0.000162715 | KEGG pathway |
| negative regulation of protein kinase activity | 0.004022012 | GO:0006469 |
| double-strand break repair | 0.004022012 | GO:0006302 |
| meiotic cell cycle | 0.004022012 | GO:0051321 |
| isoleucyl-tRNA aminoacylation | 0.004022012 | GO:0006428 |
| Mre11 complex | 0.004048164 | GO:0030870 |
| euchromatin | 0.004048164 | GO:0000791 |
| synaptonemal complex | 0.004721811 | GO:0000795 |
| pseudouridine synthesis | 0.005789986 | GO:0001522 |
| regulation of translational fidelity | 0.006431891 | GO:0006450 |
| DNA topoisomerase activity | 0.011551093 | GO:0003916 |
| protein kinase inhibitor activity | 0.011551093 | GO:0004860 |
| double-stranded RNA binding | 0.011551093 | GO:0003725 |
| isoleucine-tRNA ligase activity | 0.011551093 | GO:0004822 |
| protein kinase binding | 0.014135837 | GO:0019901 |
| aminoacyl-tRNA editing activity | 0.014135837 | GO:0002161 |
| pseudouridine synthase activity | 0.014135837 | GO:0009982 |
| Aminoacyl-tRNA biosynthesis | 0.016944738 | KEGG pathway |
| manganese ion binding | 0.01779537 | GO:0030145 |
| endonuclease activity | 0.01779537 | GO:0004519 |
| 3'-5' exonuclease activity | 0.01779537 | GO:0008408 |
| nucleic acid phosphodiester bond hydrolysis | 0.027467668 | GO:0090305 |
Module member annotation
| Gene ID | Ortholog in Arabidopsis (Blast E-value) | Annotation in Arabidopsis |
|---|---|---|
| CRO_T006011 | AT4G10320 (7.00E-159) | tRNA synthetase class I (I, L, M and V) family protein |
| CRO_T007161 | AT2G32000 (2.00E-43) | DNA topoisomerase, type IA, core |
| CRO_T016194 | AT5G54260 (0) | ATMRE11|ARABIDOPSIS MEIOTIC RECOMBINATION 11; MRE11|MEIOTIC RECOMBINATION 11 |
| CRO_T028357 | AT2G15270 (1.00E-26) | unknown protein |
| CRO_T029001 | AT3G04820 (8.00E-122) | Pseudouridine synthase family protein |
| CRO_T032992 | AT1G67120 (3.00E-11) | MDN1|MIDASIN 1 |
Direct connection functional modules
| Module ID | Function Annotation | Overlap condition |
|---|---|---|
| TissueCFM000231 | Other glycan degradation cellulose biosynthesis negative regulation of protein kinase activity protein kinase inhibitor activity formation of glycosidic bonds, GlycosylTransferases: GTnc Protein_kinases_phosphatases, PPC:2.1.4: GmPK6/AtMRK1 Family mannose metabolic process protein deglycosylation alpha-mannosidase activity double-stranded RNA binding protein kinase binding cellulose synthase (UDP-forming) activity cellulose biosynthetic process | details |
| TissueCFM000457 | negative regulation of protein kinase activity protein kinase inhibitor activity peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity double-stranded RNA binding recognition of pollen Transcription_related, Transcription regulator: SWI/SNF-BAF60b protein kinase binding Protein_kinases_phosphatases, PPC:1.9.2: S Domain Kinase (Type 2) lipid binding | details |
| TissueCFM000477 | protein retention in Golgi apparatus negative regulation of protein kinase activity intracellular protein transport meiotic cell cycle shoot system morphogenesis double-strand break repair euchromatin Mre11 complex Protein_kinases_phosphatases, PPC:1.16.1: Receptor Like Cytoplasmic Kinase II Transcription_related, Transcription factor: G2-like Ubiquitin_Proteasome_system, DUB: ULP Ubiquitin_Proteasome_system, DUB: USP synaptonemal complex retromer complex protein kinase inhibitor activity Golgi transport complex FoxO signaling pathway meristem structural organization Golgi organization retrograde vesicle-mediated transport, Golgi to ER cell growth retrograde transport, endosome to Golgi protein deubiquitination double-stranded RNA binding thiol-dependent ubiquitinyl hydrolase activity protein kinase binding manganese ion binding 3'-5' exonuclease activity endonuclease activity | details |
| TissueCFM000630 | cellulose biosynthesis cellulose synthase (UDP-forming) activity cellulose biosynthetic process cell wall organization mRNA surveillance pathway carbohydrate homeostasis negative regulation of protein kinase activity sulfate transport cellular response to sucrose stimulus embryonic root morphogenesis protein dephosphorylation L-arabinose metabolic process plant-type primary cell wall biogenesis calcium ion transport osmosensory signaling pathway | details |
| TissueCFM001250 | Aminoacyl-tRNA biosynthesis Alzheimer's disease Transcription_related, Transcription factor: BBR-BPC mitochondrial alanyl-tRNA aminoacylation isoleucyl-tRNA aminoacylation peptide catabolic process regulation of translational fidelity Cul3-RING ubiquitin ligase complex alanine-tRNA ligase activity isoleucine-tRNA ligase activity mitochondrion cytosol aminoacyl-tRNA editing activity tRNA binding tRNA modification protein processing zinc ion binding metalloendopeptidase activity amino acid binding proteolysis involved in cellular protein catabolic process | details |
| TissueCFM001254 | ARF guanyl-nucleotide exchange factor activity regulation of ARF protein signal transduction positive regulation of GTPase activity formation of glycosidic bonds, GlycosylTransferases: GTnc UDP-glucosylation negative regulation of protein kinase activity attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation tetracyclic triterpenoid biosynthetic process meiotic sister chromatid cohesion, centromeric protein kinase inhibitor activity UDP-glucose:glycoprotein glucosyltransferase activity isoleucyl-tRNA aminoacylation cycloartenol synthase activity mangrove triterpenoid biosynthesis plant sterol biosynthesis II isoleucine-tRNA ligase activity double-stranded RNA binding carboxypeptidase activity aminoacyl-tRNA editing activity regulation of translational fidelity protein kinase binding plant sterol biosynthesis protein glycosylation | details |
| TissueCFM001346 | Ribosome biogenesis in eukaryotes preribosome isoleucyl-tRNA aminoacylation regulation of translational fidelity aminoacyl-tRNA editing activity isoleucine-tRNA ligase activity ribosome biogenesis Aminoacyl-tRNA biosynthesis formation of glycosidic bonds, GlycosylTransferases: GTnc | details |
| TissueCFM001513 | negative regulation of protein kinase activity isoleucyl-tRNA aminoacylation regulation of translational fidelity protein kinase inhibitor activity double-stranded RNA binding isoleucine-tRNA ligase activity aminoacyl-tRNA editing activity protein kinase binding Aminoacyl-tRNA biosynthesis | details |
| TissueCFM001618 | attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation negative regulation of protein kinase activity meiotic sister chromatid cohesion, centromeric isoleucyl-tRNA aminoacylation regulation of translational fidelity isoleucine-tRNA ligase activity Rab guanyl-nucleotide exchange factor activity double-stranded RNA binding protein kinase inhibitor activity carboxypeptidase activity aminoacyl-tRNA editing activity recycling endosome protein kinase binding Aminoacyl-tRNA biosynthesis Cell cycle positive regulation of GTPase activity carbohydrate binding | details |
| TissueCFM001619 | Alzheimer's disease recycling endosome Cul3-RING ubiquitin ligase complex regulation of DNA-templated transcription, elongation isoleucyl-tRNA aminoacylation peptide catabolic process Rab guanyl-nucleotide exchange factor activity isoleucine-tRNA ligase activity nucleobase-containing compound metabolic process regulation of translational fidelity aminoacyl-tRNA editing activity Aminoacyl-tRNA biosynthesis protein processing positive regulation of GTPase activity regulation of transcription from RNA polymerase II promoter proteolysis involved in cellular protein catabolic process Ubiquitin_Proteasome_system, E3 adaptor: F-box metalloendopeptidase activity | details |
| TissueCFM001707 | isoleucyl-tRNA aminoacylation regulation of translational fidelity aminoacyl-tRNA editing activity isoleucine-tRNA ligase activity Aminoacyl-tRNA biosynthesis | details |
Expression profiles
 Show details about module gene expression profiling |