TissueCFM001250's detailed annotation
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Protein: Yellow color--query protein Green color--interaction proteins. Interaction line: Pink--proteins own interaction and positive co-expression relationship with target protein Blue--proteins own interaction and negative co-expression relationship with target protein Orange--proteins own interaction and protein-protein relationship with target protein |
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Module annotation (GSEA enrichment result)
| Function Annotation | FDR | Gene Ontolog |
|---|---|---|
| Aminoacyl-tRNA biosynthesis | 0.000227506 | KEGG pathway |
| Alzheimer's disease | 0.001551052 | KEGG pathway |
| Transcription_related, Transcription factor: BBR-BPC | 0.003722194 | TF family |
| mitochondrial alanyl-tRNA aminoacylation | 0.007494288 | GO:0070143 |
| isoleucyl-tRNA aminoacylation | 0.007494288 | GO:0006428 |
| peptide catabolic process | 0.007494288 | GO:0043171 |
| regulation of translational fidelity | 0.013481348 | GO:0006450 |
| Cul3-RING ubiquitin ligase complex | 0.015505016 | GO:0031463 |
| alanine-tRNA ligase activity | 0.015794952 | GO:0004813 |
| isoleucine-tRNA ligase activity | 0.015794952 | GO:0004822 |
| mitochondrion | 0.016707329 | GO:0005739 |
| cytosol | 0.016707329 | GO:0005829 |
| aminoacyl-tRNA editing activity | 0.017100582 | GO:0002161 |
| tRNA binding | 0.017100582 | GO:0000049 |
| tRNA modification | 0.019448904 | GO:0006400 |
| protein processing | 0.019448904 | GO:0016485 |
| zinc ion binding | 0.03148925 | GO:0008270 |
| metalloendopeptidase activity | 0.03148925 | GO:0004222 |
| amino acid binding | 0.03148925 | GO:0016597 |
| proteolysis involved in cellular protein catabolic process | 0.040897077 | GO:0051603 |
Module member annotation
| Gene ID | Ortholog in Arabidopsis (Blast E-value) | Annotation in Arabidopsis |
|---|---|---|
| CRO_T006011 | AT4G10320 (7.00E-159) | tRNA synthetase class I (I, L, M and V) family protein |
| CRO_T012730 | - | - |
| CRO_T014227 | AT3G27150 (6.00E-22) | Galactose oxidase/kelch repeat superfamily protein |
| CRO_T018695 | AT1G50200 (0) | ALATS|Alanyl-tRNA synthetase |
| CRO_T023280 | AT1G71490 (0) | Tetratricopeptide repeat (TPR)-like superfamily protein |
| CRO_T028064 | AT1G06900 (6.00E-113) | Insulinase (Peptidase family M16) family protein |
| CRO_T029282 | AT1G14685 (2.00E-78) | ATBPC2|BASIC PENTACYSTEINE 2 |
Direct connection functional modules
| Module ID | Function Annotation | Overlap condition |
|---|---|---|
| TissueCFM000055 | molybdenum cofactor biosynthesis | details |
| TissueCFM000075 | methylerythritol phosphate pathway II methylerythritol phosphate pathway I Terpenoid backbone biosynthesis secologanin and strictosidine biosynthesis terpenoid biosynthetic process isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway oxidation-reduction process monoterpenoid biosynthetic process geraniol and geranial biosynthesis acetaldehyde biosynthesis I pyruvate fermentation to ethanol II Transcription_related, Transcription factor: bHLH heme binding iron ion binding (3S)-linalool biosynthesis formaldehyde oxidation II (glutathione-dependent) geranyl diphosphate biosynthesis isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process steroid hormone mediated signaling pathway geranyl diphosphate metabolic process | details |
| TissueCFM000127 | Transcription_related, Transcription factor: BBR-BPC integral component of lumenal side of endoplasmic reticulum membrane Golgi-associated vesicle membrane integral component of cytoplasmic side of endoplasmic reticulum membrane lysosomal membrane ribonucleoside-diphosphate reductase complex membrane protein proteolysis signal peptide processing pollen germination deoxyribonucleotide biosynthetic process aspartic endopeptidase activity, intramembrane cleaving ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | details |
| TissueCFM000576 | Transcription_related, Transcription factor: BBR-BPC | details |
| TissueCFM000683 | Transcription_related, Transcription factor: BBR-BPC | details |
| TissueCFM001085 | ceramide degradation Transcription_related, Transcription factor: BBR-BPC peptide-serine-N-acetyltransferase activity D-erythro-sphingosine kinase activity peptide-glutamate-N-acetyltransferase activity positive regulation of histone methylation N-terminal peptidyl-glutamic acid acetylation N-terminal peptidyl-serine acetylation internal protein amino acid acetylation NatA complex sphingolipid biosynthesis (plants) sphingolipid biosynthetic process regulation of RNA metabolic process Transcription_related, Transcription regulator: GNAT system development regulation of shoot system development cytosolic ribosome clathrin adaptor complex phospholipid-translocating ATPase activity phospholipid translocation regulation of gene expression Endocytosis plasma membrane response to stimulus single-organism cellular process protein transporter activity | details |
| TissueCFM001116 | Homologous recombination negative regulation of protein kinase activity double-strand break repair meiotic cell cycle isoleucyl-tRNA aminoacylation Mre11 complex euchromatin synaptonemal complex pseudouridine synthesis regulation of translational fidelity DNA topoisomerase activity protein kinase inhibitor activity double-stranded RNA binding isoleucine-tRNA ligase activity protein kinase binding aminoacyl-tRNA editing activity pseudouridine synthase activity Aminoacyl-tRNA biosynthesis manganese ion binding endonuclease activity 3'-5' exonuclease activity nucleic acid phosphodiester bond hydrolysis | details |
| TissueCFM001254 | ARF guanyl-nucleotide exchange factor activity regulation of ARF protein signal transduction positive regulation of GTPase activity formation of glycosidic bonds, GlycosylTransferases: GTnc UDP-glucosylation negative regulation of protein kinase activity attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation tetracyclic triterpenoid biosynthetic process meiotic sister chromatid cohesion, centromeric protein kinase inhibitor activity UDP-glucose:glycoprotein glucosyltransferase activity isoleucyl-tRNA aminoacylation cycloartenol synthase activity mangrove triterpenoid biosynthesis plant sterol biosynthesis II isoleucine-tRNA ligase activity double-stranded RNA binding carboxypeptidase activity aminoacyl-tRNA editing activity regulation of translational fidelity protein kinase binding plant sterol biosynthesis protein glycosylation | details |
| TissueCFM001326 | formation of glycosidic bonds, GlycosylTransferases: GTnc Transcription_related, Transcription factor: BBR-BPC regulation of biological process folic acid-containing compound biosynthetic process | details |
| TissueCFM001346 | Ribosome biogenesis in eukaryotes preribosome isoleucyl-tRNA aminoacylation regulation of translational fidelity aminoacyl-tRNA editing activity isoleucine-tRNA ligase activity ribosome biogenesis Aminoacyl-tRNA biosynthesis formation of glycosidic bonds, GlycosylTransferases: GTnc | details |
| TissueCFM001510 | cellular response to stress positive regulation of kinase activity UDP-glucosylation glucan 1,4-alpha-maltotetraohydrolase activity UDP-glucose:glycoprotein glucosyltransferase activity regulation of translation formation of glycosidic bonds, GlycosylTransferases: GTnc alpha-amylase activity regulation of protein kinase activity Transcription_related, Transcription factor: BBR-BPC protein kinase regulator activity hydrolysis and/or rearrangement of glycosidic bonds, Glycoside Hydrolases: GHnc protein kinase binding ribosome binding protein glycosylation Transcription_related, Transcription regulator: SNF2 RNA degradation | details |
| TissueCFM001513 | negative regulation of protein kinase activity isoleucyl-tRNA aminoacylation regulation of translational fidelity protein kinase inhibitor activity double-stranded RNA binding isoleucine-tRNA ligase activity aminoacyl-tRNA editing activity protein kinase binding Aminoacyl-tRNA biosynthesis | details |
| TissueCFM001550 | Plant-pathogen interaction cation binding single-organism cellular process protein dephosphorylation protein serine/threonine phosphatase activity | details |
| TissueCFM001618 | attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation negative regulation of protein kinase activity meiotic sister chromatid cohesion, centromeric isoleucyl-tRNA aminoacylation regulation of translational fidelity isoleucine-tRNA ligase activity Rab guanyl-nucleotide exchange factor activity double-stranded RNA binding protein kinase inhibitor activity carboxypeptidase activity aminoacyl-tRNA editing activity recycling endosome protein kinase binding Aminoacyl-tRNA biosynthesis Cell cycle positive regulation of GTPase activity carbohydrate binding | details |
| TissueCFM001619 | Alzheimer's disease recycling endosome Cul3-RING ubiquitin ligase complex regulation of DNA-templated transcription, elongation isoleucyl-tRNA aminoacylation peptide catabolic process Rab guanyl-nucleotide exchange factor activity isoleucine-tRNA ligase activity nucleobase-containing compound metabolic process regulation of translational fidelity aminoacyl-tRNA editing activity Aminoacyl-tRNA biosynthesis protein processing positive regulation of GTPase activity regulation of transcription from RNA polymerase II promoter proteolysis involved in cellular protein catabolic process Ubiquitin_Proteasome_system, E3 adaptor: F-box metalloendopeptidase activity | details |
| TissueCFM001707 | isoleucyl-tRNA aminoacylation regulation of translational fidelity aminoacyl-tRNA editing activity isoleucine-tRNA ligase activity Aminoacyl-tRNA biosynthesis | details |
| TissueCFM001776 | Alzheimer's disease Protein_kinases_phosphatases, PPC:4.2.6: IRE/NPH/PI dependent/S6 Kinase phosphatidylcholine catabolic process peptide catabolic process phospholipase D activity UFM1 hydrolase activity N-acylphosphatidylethanolamine-specific phospholipase D activity potassium ion transport choline biosynthesis III phosphatidate metabolism, as a signaling molecule phospholipases Glycerophospholipid metabolism lipid catabolic process protein processing peptidyl-serine phosphorylation proteolysis involved in cellular protein catabolic process metalloendopeptidase activity intracellular signal transduction | details |
Expression profiles
 Show details about module gene expression profiling |