TissueCFM001346's detailed annotation
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Protein: Yellow color--query protein Green color--interaction proteins. Interaction line: Pink--proteins own interaction and positive co-expression relationship with target protein Blue--proteins own interaction and negative co-expression relationship with target protein Orange--proteins own interaction and protein-protein relationship with target protein |
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Module annotation (GSEA enrichment result)
| Function Annotation | FDR | Gene Ontolog |
|---|---|---|
| Ribosome biogenesis in eukaryotes | 9.80E-07 | KEGG pathway |
| preribosome | 0.001950499 | GO:0030684 |
| isoleucyl-tRNA aminoacylation | 0.004875166 | GO:0006428 |
| regulation of translational fidelity | 0.005847174 | GO:0006450 |
| aminoacyl-tRNA editing activity | 0.008121675 | GO:0002161 |
| isoleucine-tRNA ligase activity | 0.008121675 | GO:0004822 |
| ribosome biogenesis | 0.010056006 | GO:0042254 |
| Aminoacyl-tRNA biosynthesis | 0.016944738 | KEGG pathway |
| formation of glycosidic bonds, GlycosylTransferases: GTnc | 0.042670298 | cazy family |
Module member annotation
| Gene ID | Ortholog in Arabidopsis (Blast E-value) | Annotation in Arabidopsis |
|---|---|---|
| CRO_T000065 | AT1G06720 (5.00E-115) | P-loop containing nucleoside triphosphate hydrolases superfamily protein |
| CRO_T004819 | AT1G63130 (7.00E-40) | Tetratricopeptide repeat (TPR)-like superfamily protein |
| CRO_T006011 | AT4G10320 (7.00E-159) | tRNA synthetase class I (I, L, M and V) family protein |
| CRO_T008603 | AT3G63090 (6.00E-142) | Ubiquitin carboxyl-terminal hydrolase family protein |
| CRO_T020193 | AT3G06530 (2.00E-168) | ARM repeat superfamily protein |
| CRO_T025865 | AT3G06530 (2.00E-38) | ARM repeat superfamily protein |
Direct connection functional modules
| Module ID | Function Annotation | Overlap condition |
|---|---|---|
| TissueCFM000457 | negative regulation of protein kinase activity protein kinase inhibitor activity peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity double-stranded RNA binding recognition of pollen Transcription_related, Transcription regulator: SWI/SNF-BAF60b protein kinase binding Protein_kinases_phosphatases, PPC:1.9.2: S Domain Kinase (Type 2) lipid binding | details |
| TissueCFM000458 | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity recognition of pollen Protein_kinases_phosphatases, PPC:1.9.2: S Domain Kinase (Type 2) mRNA splicing, via spliceosome Spliceosome spliceosomal complex | details |
| TissueCFM001066 | N-terminal peptidyl-glutamic acid acetylation positive regulation of transcription from RNA polymerase I promoter internal protein amino acid acetylation N-terminal peptidyl-serine acetylation N-terminal peptidyl-methionine acetylation t-UTP complex NatB complex NatA complex peptide-glutamate-N-acetyltransferase activity peptide-serine-N-acetyltransferase activity cytosolic ribosome 90S preribosome Transcription_related, Transcription regulator: GNAT spliceosomal complex peptide alpha-N-acetyltransferase activity snoRNA binding hydroquinone:oxygen oxidoreductase activity lignin catabolic process Autophagy - yeast maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) mRNA splicing, via spliceosome small-subunit processome Ribosome biogenesis in eukaryotes | details |
| TissueCFM001067 | N-terminal peptidyl-glutamic acid acetylation internal protein amino acid acetylation N-terminal peptidyl-serine acetylation peptide-glutamate-N-acetyltransferase activity peptide-serine-N-acetyltransferase activity NatA complex cytosolic ribosome spliceosomal complex Transcription_related, Transcription regulator: GNAT mRNA splicing, via spliceosome Spliceosome | details |
| TissueCFM001116 | Homologous recombination negative regulation of protein kinase activity double-strand break repair meiotic cell cycle isoleucyl-tRNA aminoacylation Mre11 complex euchromatin synaptonemal complex pseudouridine synthesis regulation of translational fidelity DNA topoisomerase activity protein kinase inhibitor activity double-stranded RNA binding isoleucine-tRNA ligase activity protein kinase binding aminoacyl-tRNA editing activity pseudouridine synthase activity Aminoacyl-tRNA biosynthesis manganese ion binding endonuclease activity 3'-5' exonuclease activity nucleic acid phosphodiester bond hydrolysis | details |
| TissueCFM001250 | Aminoacyl-tRNA biosynthesis Alzheimer's disease Transcription_related, Transcription factor: BBR-BPC mitochondrial alanyl-tRNA aminoacylation isoleucyl-tRNA aminoacylation peptide catabolic process regulation of translational fidelity Cul3-RING ubiquitin ligase complex alanine-tRNA ligase activity isoleucine-tRNA ligase activity mitochondrion cytosol aminoacyl-tRNA editing activity tRNA binding tRNA modification protein processing zinc ion binding metalloendopeptidase activity amino acid binding proteolysis involved in cellular protein catabolic process | details |
| TissueCFM001254 | ARF guanyl-nucleotide exchange factor activity regulation of ARF protein signal transduction positive regulation of GTPase activity formation of glycosidic bonds, GlycosylTransferases: GTnc UDP-glucosylation negative regulation of protein kinase activity attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation tetracyclic triterpenoid biosynthetic process meiotic sister chromatid cohesion, centromeric protein kinase inhibitor activity UDP-glucose:glycoprotein glucosyltransferase activity isoleucyl-tRNA aminoacylation cycloartenol synthase activity mangrove triterpenoid biosynthesis plant sterol biosynthesis II isoleucine-tRNA ligase activity double-stranded RNA binding carboxypeptidase activity aminoacyl-tRNA editing activity regulation of translational fidelity protein kinase binding plant sterol biosynthesis protein glycosylation | details |
| TissueCFM001513 | negative regulation of protein kinase activity isoleucyl-tRNA aminoacylation regulation of translational fidelity protein kinase inhibitor activity double-stranded RNA binding isoleucine-tRNA ligase activity aminoacyl-tRNA editing activity protein kinase binding Aminoacyl-tRNA biosynthesis | details |
| TissueCFM001618 | attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation negative regulation of protein kinase activity meiotic sister chromatid cohesion, centromeric isoleucyl-tRNA aminoacylation regulation of translational fidelity isoleucine-tRNA ligase activity Rab guanyl-nucleotide exchange factor activity double-stranded RNA binding protein kinase inhibitor activity carboxypeptidase activity aminoacyl-tRNA editing activity recycling endosome protein kinase binding Aminoacyl-tRNA biosynthesis Cell cycle positive regulation of GTPase activity carbohydrate binding | details |
| TissueCFM001619 | Alzheimer's disease recycling endosome Cul3-RING ubiquitin ligase complex regulation of DNA-templated transcription, elongation isoleucyl-tRNA aminoacylation peptide catabolic process Rab guanyl-nucleotide exchange factor activity isoleucine-tRNA ligase activity nucleobase-containing compound metabolic process regulation of translational fidelity aminoacyl-tRNA editing activity Aminoacyl-tRNA biosynthesis protein processing positive regulation of GTPase activity regulation of transcription from RNA polymerase II promoter proteolysis involved in cellular protein catabolic process Ubiquitin_Proteasome_system, E3 adaptor: F-box metalloendopeptidase activity | details |
| TissueCFM001707 | isoleucyl-tRNA aminoacylation regulation of translational fidelity aminoacyl-tRNA editing activity isoleucine-tRNA ligase activity Aminoacyl-tRNA biosynthesis | details |
Expression profiles
 Show details about module gene expression profiling |