TissueCFM001448's detailed annotation
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Protein: Yellow color--query protein Green color--interaction proteins. Interaction line: Pink--proteins own interaction and positive co-expression relationship with target protein Blue--proteins own interaction and negative co-expression relationship with target protein Orange--proteins own interaction and protein-protein relationship with target protein |
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Module annotation (GSEA enrichment result)
| Function Annotation | FDR | Gene Ontolog |
|---|---|---|
| Protein processing in endoplasmic reticulum | 0.001828123 | KEGG pathway |
| internal protein amino acid acetylation | 0.003009763 | GO:0006475 |
| N-terminal peptidyl-glutamic acid acetylation | 0.003009763 | GO:0018002 |
| N-terminal peptidyl-serine acetylation | 0.003009763 | GO:0017198 |
| peptide-serine-N-acetyltransferase activity | 0.004514645 | GO:1990189 |
| peptide-glutamate-N-acetyltransferase activity | 0.004514645 | GO:1990190 |
| NatA complex | 0.005782675 | GO:0031415 |
| Golgi apparatus part | 0.005782675 | GO:0044431 |
| Transcription_related, Transcription regulator: GNAT | 0.006903152 | TF family |
| Ubiquitin_Proteasome_system, E3 adaptor: Cullin | 0.006903152 | ubs family |
| intracellular transport | 0.00789771 | GO:0046907 |
| cytosolic ribosome | 0.009246129 | GO:0022626 |
| cullin-RING ubiquitin ligase complex | 0.009246129 | GO:0031461 |
| COPII vesicle coat | 0.009246129 | GO:0030127 |
| vacuolar transport | 0.010827144 | GO:0007034 |
| mRNA surveillance pathway | 0.022207137 | KEGG pathway |
| ER to Golgi vesicle-mediated transport | 0.029265076 | GO:0006888 |
| protein ubiquitination involved in ubiquitin-dependent protein catabolic process | 0.031492961 | GO:0042787 |
| vesicle-mediated transport | 0.040422212 | GO:0016192 |
Module member annotation
| Gene ID | Ortholog in Arabidopsis (Blast E-value) | Annotation in Arabidopsis |
|---|---|---|
| CRO_T005031 | AT3G07100 (0) | ERMO2|ENDOPLASMIC RETICULUM MORPHOLOGY 2 |
| CRO_T009118 | AT1G03150 (1.00E-23) | Acyl-CoA N-acyltransferases (NAT) superfamily protein |
| CRO_T009803 | AT1G02980 (0) | CUL2|cullin 2 |
| CRO_T014523 | AT1G72960 (0) | Root hair defective 3 GTP-binding protein (RHD3) |
| CRO_T014604 | AT4G19490 (0) | ATVPS54|VPS54 HOMOLOG |
| CRO_T031661 | AT2G41060 (5.00E-17) | RNA-binding (RRM/RBD/RNP motifs) family protein |
Direct connection functional modules
| Module ID | Function Annotation | Overlap condition |
|---|---|---|
| TissueCFM000253 | peptide-serine-N-acetyltransferase activity peptide-glutamate-N-acetyltransferase activity N-terminal peptidyl-glutamic acid acetylation internal protein amino acid acetylation N-terminal peptidyl-serine acetylation NatA complex Transcription_related, Transcription regulator: GNAT cytosolic ribosome | details |
| TissueCFM000264 | NatA complex N-terminal peptidyl-serine acetylation N-terminal peptidyl-glutamic acid acetylation internal protein amino acid acetylation peptide-serine-N-acetyltransferase activity peptide-glutamate-N-acetyltransferase activity Transcription_related, Transcription regulator: GNAT cytosolic ribosome RNA binding ARF guanyl-nucleotide exchange factor activity spliceosomal complex regulation of ARF protein signal transduction ribonuclease III activity MicroRNAs in cancer RNA phosphodiester bond hydrolysis, endonucleolytic positive regulation of GTPase activity RNA processing mRNA splicing, via spliceosome RNA degradation | details |
| TissueCFM000405 | N-terminal peptidyl-serine acetylation N-terminal peptidyl-glutamic acid acetylation internal protein amino acid acetylation NatA complex peptide-serine-N-acetyltransferase activity peptide-glutamate-N-acetyltransferase activity Glucagon signaling pathway cytosolic ribosome Transcription_related, Transcription regulator: GNAT ATP-dependent helicase activity RNA degradation | details |
| TissueCFM000523 | intracellular protein transport 1-phosphatidylinositol 4-kinase activity phosphatidylinositol-mediated signaling membrane coat COPII vesicle coat phosphatidylinositol phosphorylation 3-phosphoinositide biosynthesis D-myo-inositol (1,4,5)-trisphosphate biosynthesis very long chain fatty acid biosynthesis I ER to Golgi vesicle-mediated transport Inositol phosphate metabolism Lysosome vesicle-mediated transport | details |
| TissueCFM000542 | Glucagon signaling pathway N-terminal peptidyl-serine acetylation N-terminal peptidyl-glutamic acid acetylation internal protein amino acid acetylation peptide-glutamate-N-acetyltransferase activity peptide-serine-N-acetyltransferase activity negative regulation of nucleic acid-templated transcription transcription corepressor activity NatA complex Transcription_related, Transcription regulator: GNAT cytosolic ribosome | details |
| TissueCFM000747 | peptide-serine-N-acetyltransferase activity NatB complex NatA complex peptide-glutamate-N-acetyltransferase activity N-terminal peptidyl-glutamic acid acetylation N-terminal peptidyl-serine acetylation internal protein amino acid acetylation N-terminal peptidyl-methionine acetylation DNA topoisomerase type I activity cellular component organization reproductive structure development DNA topological change Transcription_related, Transcription regulator: TRAF Ubiquitin_Proteasome_system, SOCS/VHL/BC-box: 3-box Transcription_related, Transcription regulator: GNAT cytosolic ribosome single organism reproductive process peptide alpha-N-acetyltransferase activity post-embryonic development hydroquinone:oxygen oxidoreductase activity lignin catabolic process Ubiquitin_Proteasome_system, E3 adaptor: BTB Regulation of actin cytoskeleton single-organism cellular process Homologous recombination Ubiquitin mediated proteolysis | details |
| TissueCFM001061 | D-myo-inositol (1,4,5)-trisphosphate degradation peptide-serine-N-acetyltransferase activity peptide-glutamate-N-acetyltransferase activity internal protein amino acid acetylation N-terminal peptidyl-serine acetylation N-terminal peptidyl-glutamic acid acetylation NatA complex voltage-gated chloride channel activity Protein_kinases_phosphatases, PPC:3.1.1: Casein Kinase I Family Transcription_related, Transcription regulator: GNAT phosphatidylinositol dephosphorylation chloride transport Wnt signaling pathway regulation of cell shape regulation of anion transmembrane transport cytosolic ribosome Endocytosis hyperosmotic salinity response ion transmembrane transport peptidyl-serine phosphorylation Protein processing in endoplasmic reticulum | details |
| TissueCFM001066 | N-terminal peptidyl-glutamic acid acetylation positive regulation of transcription from RNA polymerase I promoter internal protein amino acid acetylation N-terminal peptidyl-serine acetylation N-terminal peptidyl-methionine acetylation t-UTP complex NatB complex NatA complex peptide-glutamate-N-acetyltransferase activity peptide-serine-N-acetyltransferase activity cytosolic ribosome 90S preribosome Transcription_related, Transcription regulator: GNAT spliceosomal complex peptide alpha-N-acetyltransferase activity snoRNA binding hydroquinone:oxygen oxidoreductase activity lignin catabolic process Autophagy - yeast maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) mRNA splicing, via spliceosome small-subunit processome Ribosome biogenesis in eukaryotes | details |
| TissueCFM001067 | N-terminal peptidyl-glutamic acid acetylation internal protein amino acid acetylation N-terminal peptidyl-serine acetylation peptide-glutamate-N-acetyltransferase activity peptide-serine-N-acetyltransferase activity NatA complex cytosolic ribosome spliceosomal complex Transcription_related, Transcription regulator: GNAT mRNA splicing, via spliceosome Spliceosome | details |
| TissueCFM001085 | ceramide degradation Transcription_related, Transcription factor: BBR-BPC peptide-serine-N-acetyltransferase activity D-erythro-sphingosine kinase activity peptide-glutamate-N-acetyltransferase activity positive regulation of histone methylation N-terminal peptidyl-glutamic acid acetylation N-terminal peptidyl-serine acetylation internal protein amino acid acetylation NatA complex sphingolipid biosynthesis (plants) sphingolipid biosynthetic process regulation of RNA metabolic process Transcription_related, Transcription regulator: GNAT system development regulation of shoot system development cytosolic ribosome clathrin adaptor complex phospholipid-translocating ATPase activity phospholipid translocation regulation of gene expression Endocytosis plasma membrane response to stimulus single-organism cellular process protein transporter activity | details |
| TissueCFM001146 | transcriptional repressor complex Golgi apparatus part Insulin signaling pathway Steroid biosynthesis intracellular transport vacuolar transport Cell cycle Transcription_related, Transcription factor: MYB-related Transcription_related, Transcription regulator: SNF2 exocyst cell part histone binding exocytosis membrane vesicle-mediated transport | details |
| TissueCFM001199 | D-myo-inositol (1,4,5)-trisphosphate degradation Transcription_related, Transcription factor: SBP Transcription_related, Transcription regulator: GNAT peptide-serine-N-acetyltransferase activity peptide-glutamate-N-acetyltransferase activity long-day photoperiodism N-terminal peptidyl-serine acetylation N-terminal peptidyl-glutamic acid acetylation stem cell fate determination internal protein amino acid acetylation meristem maintenance cellular calcium ion homeostasis nuclear-transcribed mRNA catabolic process, nonsense-mediated decay pollen maturation NatA complex sugar mediated signaling pathway phosphatidylinositol dephosphorylation cellular response to phosphate starvation pollen germination response to wounding nucleic acid metabolic process cellular macromolecule metabolic process cation transmembrane transport salicylic acid mediated signaling pathway jasmonic acid mediated signaling pathway cation-transporting ATPase activity | details |
| TissueCFM001371 | actin binding N-terminal peptidyl-glutamic acid acetylation internal protein amino acid acetylation N-terminal peptidyl-serine acetylation peptide-serine-N-acetyltransferase activity peptide-glutamate-N-acetyltransferase activity NatA complex phosphatidylinositol-mediated signaling cytoskeleton organization Transcription_related, Transcription regulator: GNAT Ubiquitin_Proteasome_system, DUB: USP 1-phosphatidylinositol 4-kinase activity DNA topoisomerase type I activity 3-phosphoinositide biosynthesis D-myo-inositol (1,4,5)-trisphosphate biosynthesis motor activity myosin complex cytosolic ribosome spliceosomal complex phosphatidylinositol phosphorylation single-organism process mRNA splicing, via spliceosome Inositol phosphate metabolism | details |
| TissueCFM001427 | vesicle-mediated transport intracellular protein transport transcriptional repressor complex Golgi apparatus part intracellular transport Cell cycle vacuolar transport Lysosome Transcription_related, Transcription factor: MYB-related very long chain fatty acid biosynthesis I membrane coat | details |
| TissueCFM001447 | vesicle-mediated transport protein transporter activity intracellular protein transport Ubiquitin_Proteasome_system, E3 adaptor: Cullin intracellular transport vacuolar transport MAPK signaling pathway - fly protein import into nucleus nuclear envelope cullin-RING ubiquitin ligase complex membrane coat clathrin adaptor complex Golgi apparatus part cytosol protein ubiquitination involved in ubiquitin-dependent protein catabolic process Lysosome Ran GTPase binding ubiquitin protein ligase binding signal transduction Endocytosis | details |
| TissueCFM001449 | phosphatidylethanolamine biosynthesis I FoxO signaling pathway Protein digestion and absorption Ubiquitin_Proteasome_system, DUB: ULP Ubiquitin_Proteasome_system, DUB: USP Ubiquitin_Proteasome_system, E3: HECT very long chain fatty acid biosynthesis I Glycerophospholipid metabolism | details |
| TissueCFM001451 | phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity peptide-serine-N-acetyltransferase activity peptide-glutamate-N-acetyltransferase activity Golgi apparatus recycling endosome NatA complex Rab guanyl-nucleotide exchange factor activity N-terminal peptidyl-serine acetylation N-terminal peptidyl-glutamic acid acetylation internal protein amino acid acetylation Transcription_related, Transcription regulator: GNAT NuA4 histone acetyltransferase complex 3-phosphoinositide biosynthesis phosphatidylinositol-3-phosphate biosynthetic process cytosolic ribosome cytoskeleton organization plant-type cell wall biogenesis hyperosmotic salinity response unidimensional cell growth positive regulation of GTPase activity protein serine/threonine phosphatase activity mRNA surveillance pathway | details |
| TissueCFM001484 | peptide-glutamate-N-acetyltransferase activity peptide-serine-N-acetyltransferase activity NatA complex N-terminal peptidyl-serine acetylation internal protein amino acid acetylation N-terminal peptidyl-glutamic acid acetylation Transcription_related, Transcription regulator: DDT protein monoubiquitination histone ubiquitination innate immune response HAUS complex cytosolic ribosome reproductive structure development spindle assembly Transcription_related, Transcription regulator: GNAT post-embryonic development single-organism cellular process Protein processing in endoplasmic reticulum | details |
| TissueCFM001580 | Protein_kinases_phosphatases, PPC:2.1.4: GmPK6/AtMRK1 Family Ubiquitin_Proteasome_system, E3 adaptor: Cullin 3-phosphoinositide biosynthesis phosphoric ester hydrolase activity transcription regulatory region sequence-specific DNA binding chromatin chromatin silencing complex cullin-RING ubiquitin ligase complex vacuole organization heterochromatin assembly phosphatidylinositol-3-phosphate biosynthetic process regulation of cell shape chromatin silencing Wnt signaling pathway Endocytosis peptidyl-serine phosphorylation protein ubiquitination involved in ubiquitin-dependent protein catabolic process regulation of cellular process Protein processing in endoplasmic reticulum ubiquitin protein ligase binding chromatin binding | details |
| TissueCFM001601 | peptide-serine-N-acetyltransferase activity peptide-glutamate-N-acetyltransferase activity N-terminal peptidyl-glutamic acid acetylation internal protein amino acid acetylation N-terminal peptidyl-serine acetylation cellulose biosynthesis NatA complex Autophagy - yeast cytosolic ribosome spliceosomal complex plasma membrane zinc ion binding cellulose synthase (UDP-forming) activity recognition of pollen formation of glycosidic bonds, GlycosylTransferases: GTnc Protein_kinases_phosphatases, PPC:1.9.2: S Domain Kinase (Type 2) Transcription_related, Transcription regulator: GNAT cellulose biosynthetic process mRNA splicing, via spliceosome Spliceosome | details |
| TissueCFM001672 | protein transporter activity Ubiquitin_Proteasome_system, E3 adaptor: Cullin vesicle-mediated transport MAPK signaling pathway - fly ribosomal protein import into nucleus protein import into nucleus, translocation protein import into nucleus, docking vacuolar transport intracellular transport NLS-bearing protein import into nucleus nuclear localization sequence binding Ran GTPase binding protein import into nucleus nuclear envelope nuclear periphery Golgi apparatus part nuclear membrane cullin-RING ubiquitin ligase complex clathrin adaptor complex ubiquitin protein ligase binding Peroxisome protein ubiquitination involved in ubiquitin-dependent protein catabolic process ubiquitin protein ligase activity | details |
| TissueCFM001673 | N-terminal peptidyl-serine acetylation N-terminal peptidyl-glutamic acid acetylation internal protein amino acid acetylation Transcription_related, Transcription regulator: GNAT long-day photoperiodism peptide-serine-N-acetyltransferase activity peptide-glutamate-N-acetyltransferase activity NatA complex nuclear-transcribed mRNA catabolic process, nonsense-mediated decay G-protein beta/gamma-subunit complex binding G-protein coupled receptor signaling pathway sugar mediated signaling pathway response to wounding salicylic acid mediated signaling pathway cytoplasmic mRNA processing body cytosolic ribosome spliceosomal complex jasmonic acid mediated signaling pathway mRNA splicing, via spliceosome defense response to bacterium signal transducer activity | details |
Expression profiles
 Show details about module gene expression profiling |