TreatCFM000747's detailed annotation
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Protein: Yellow color--query protein Green color--interaction proteins. Interaction line: Pink--proteins own interaction and positive co-expression relationship with target protein Blue--proteins own interaction and negative co-expression relationship with target protein Orange--proteins own interaction and protein-protein relationship with target protein |
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Module annotation (GSEA enrichment result)
| Function Annotation | FDR | Gene Ontolog |
|---|---|---|
| L-histidine biosynthesis | 0.021822263 | plantCyc |
| adenylosuccinate synthase activity | 0.023200312 | GO:0004019 |
| histidinol dehydrogenase activity | 0.023200312 | GO:0004399 |
| 'de novo' AMP biosynthetic process | 0.024648786 | GO:0044208 |
| endoplasmic reticulum tubular network organization | 0.024648786 | GO:0071786 |
| adenosine ribonucleotides de novo biosynthesis | 0.02755078 | plantCyc |
| endoplasmic reticulum tubular network | 0.028576279 | GO:0071782 |
| histidine biosynthetic process | 0.032803945 | GO:0000105 |
| Group II intron splicing | 0.032803945 | GO:0000373 |
| protein metabolic process | 0.032803945 | GO:0019538 |
Module member annotation
| Gene ID | Ortholog in Arabidopsis (Blast E-value) | Annotation in Arabidopsis |
|---|---|---|
| CRO_T006078 | AT4G16580 (5.00E-104) | Protein phosphatase 2C family protein |
| CRO_T008796 | AT5G54200 (9.00E-95) | Transducin/WD40 repeat-like superfamily protein |
| CRO_T011944 | AT5G63890 (0) | ATHDH|histidinol dehydrogenase; HISN8|HISTIDINE BIOSYNTHESIS 8 |
| CRO_T012136 | AT5G13890 (6.00E-07) | Family of unknown function (DUF716) |
| CRO_T017223 | AT1G29760 (1.00E-92) | Putative adipose-regulatory protein (Seipin) |
| CRO_T017783 | AT1G22310 (1.00E-36) | MBD8|methyl-CPG-binding domain 8 |
| CRO_T021032 | AT2G43110 (3.00E-29) | unknown protein |
| CRO_T023570 | AT4G31080 (3.00E-95) | Protein of unknown function (DUF2296) |
| CRO_T024145 | AT3G57610 (0) | ADSS|adenylosuccinate synthase |
| CRO_T024325 | AT1G21660 (1.00E-24) | Chaperone DnaJ-domain superfamily protein |
| CRO_T024872 | AT2G18500 (1.00E-19) | ATOFP7|OVATE FAMILY PROTEIN 7 |
| CRO_T024907 | AT4G14290 (4.00E-159) | alpha/beta-Hydrolases superfamily protein |
| CRO_T025042 | AT1G04590 (1.00E-76) | |
| CRO_T026403 | AT2G39120 (1.00E-125) | WTF9|what's this factor 9 |
| CRO_T026596 | AT4G12060 (2.00E-67) | Double Clp-N motif protein |
| CRO_T029413 | AT3G58170 (2.00E-23) | ATBS14A|BET1P/SFT1P-LIKE PROTEIN 14A |
| CRO_T030713 | AT1G16670 (3.00E-130) | Protein kinase superfamily protein |
| CRO_T033074 | - | - |
| CRO_T033305 | AT3G09630 (4.00E-125) | Ribosomal protein L4/L1 family |
Direct connection functional modules
| Module ID | Function Annotation | Overlap condition |
|---|---|---|
| TreatCFM000042 | Biosynthesis of amino acids L-histidine biosynthesis L-phenylalanine biosynthesis II L-phenylalanine biosynthesis III (cytosolic, plants) Transcription_related, Transcription factor: LOB prephenate dehydratase activity arogenate dehydratase activity histidinol dehydrogenase activity chorismate mutase activity organic cation transport histidine biosynthetic process nitrogen utilization ammonium transmembrane transport L-phenylalanine biosynthetic process nucleoside metabolic process chloroplast stroma chloroplast outer membrane ammonium transmembrane transporter activity pollen development chloroplast organization cell wall organization or biogenesis | details |
| TreatCFM000309 | actin filament depolymerization Regulation of actin cytoskeleton actin cytoskeleton endosome vacuolar membrane cytosolic large ribosomal subunit trans-Golgi network S-adenosylmethionine-dependent methyltransferase activity actin binding serine-type endopeptidase activity | details |
| TreatCFM000323 | adenylosuccinate synthase activity magnesium ion binding ATP phosphoribosyltransferase activity 'de novo' AMP biosynthetic process histidine biosynthetic process L-histidine biosynthesis pyruvate decarboxylation to acetyl CoA adenosine ribonucleotides de novo biosynthesis | details |
| TreatCFM000328 | 'de novo' AMP biosynthetic process adenylosuccinate synthase activity adenosine ribonucleotides de novo biosynthesis Ubiquitin_Proteasome_system, E3 adaptor: DWD | details |
| TreatCFM000689 | S-adenosyl-L-methionine cycle II 2'-deoxymugineic acid phytosiderophore biosynthesis baicalein degradation (hydrogen peroxide detoxification) L-methionine degradation I (to L-homocysteine) L-methionine salvage cycle I (bacteria and plants) L-methionine salvage cycle II (plants) S-adenosyl-L-methionine biosynthesis wogonin metabolism | details |
| TreatCFM000696 | 3-phosphoinositide biosynthesis endoplasmic reticulum tubular network organization clathrin-mediated endocytosis plant-type cell wall modification involved in multidimensional cell growth hydrolysis and/or rearrangement of glycosidic bonds, Glycoside Hydrolases: GHnc D-myo-inositol (1,4,5)-trisphosphate biosynthesis D-myo-inositol (1,4,5)-trisphosphate degradation apical plasma membrane endoplasmic reticulum tubular network phosphatidylinositol dephosphorylation calcium ion transmembrane transport cell wall biogenesis xyloglucan metabolic process phosphatidylinositol phosphorylation calcium-transporting ATPase activity cation binding 1-phosphatidylinositol-4-phosphate 5-kinase activity hydrolase activity Fanconi anemia pathway Inositol phosphate metabolism pollen tube | details |
| TreatCFM000732 | apical plasma membrane clathrin-mediated endocytosis pollen tube phosphatidylinositol phosphorylation Inositol phosphate metabolism 3-phosphoinositide biosynthesis D-myo-inositol (1,4,5)-trisphosphate biosynthesis 1-phosphatidylinositol-4-phosphate 5-kinase activity | details |
| TreatCFM000858 | extracellular region cytokinin-O-glucosides biosynthesis L-histidine biosynthesis histidinol dehydrogenase activity growth factor activity Biosynthesis of amino acids Ubiquitin mediated proteolysis chitinase activity chitin binding histidine biosynthetic process cell proliferation chitin catabolic process ubiquitin protein ligase binding formation of glycosidic bonds, GlycosylTransferases: GTnc Transcription_related, Transcription factor: MYB Ubiquitin_Proteasome_system, E2: UBC | details |
| TreatCFM000998 | L-leucine biosynthesis DNA-3-methyladenine glycosylase activity hydro-lyase activity protein histidine kinase binding protein metabolic process base-excision repair 2-Oxocarboxylic acid metabolism Base excision repair | details |
| TreatCFM001003 | L-histidine biosynthesis L-serine transport protein metabolic process histidine biosynthetic process histidinol dehydrogenase activity L-serine transmembrane transporter activity chloroplast stroma protein processing protein histidine kinase binding protein-cysteine S-palmitoyltransferase activity phosphatidylinositol binding pollen development Biosynthesis of amino acids Endocytosis | details |
| TreatCFM001118 | pyruvate decarboxylation to acetyl CoA auxin efflux transmembrane transporter activity protein histidine kinase binding auxin efflux protein metabolic process auxin homeostasis auxin-activated signaling pathway auxin polar transport pollen development Transcription_related, Transcription factor: bHLH | details |
| TreatCFM001294 | phosphatidylinositol binding regulation of barrier septum assembly hypoxanthine salvage inosine biosynthetic process adenosine catabolic process histidinol dehydrogenase activity flavin-linked sulfhydryl oxidase activity regulation of ruffle assembly Ubiquitin_Proteasome_system, E3: HECT Transcription_related, Transcription regulator: mTERF ATPase binding adenosine deaminase activity detoxification of reactive carbonyls in chloroplasts L-histidine biosynthesis traumatin and (Z)-3-hexen-1-yl acetate biosynthesis protein metabolic process chloroplast fission histidine biosynthetic process endosome organization trichome branching protein histidine kinase binding | details |
| TreatCFM001301 | Cytochrome_P450, Cytochrome P450: CYP85A Protein_kinases_phosphatases, PPC:4.5.6: LAMMER Kinase Family ribonuclease H2 complex fatty acid elongation -- saturated L-histidine biosynthesis L-leucine degradation I PRPP biosynthesis I L-valine degradation I octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) lipid homeostasis leucine catabolic process nucleoside metabolic process nucleotide biosynthetic process histidine biosynthetic process sodium ion transport RNA catabolic process branched-chain amino acid catabolic process fatty acid beta-oxidation using acyl-CoA dehydrogenase isovaleryl-CoA dehydrogenase activity histidinol dehydrogenase activity Valine, leucine and isoleucine degradation Brassinosteroid biosynthesis RNA-DNA hybrid ribonuclease activity ribose phosphate diphosphokinase activity | details |
| TreatCFM001328 | Nucleotide excision repair 1,3-beta-D-glucan synthase activity protein histidine kinase binding DNA-3-methyladenine glycosylase activity Base excision repair (1->3)-beta-D-glucan biosynthetic process protein metabolic process base-excision repair 1,3-beta-D-glucan synthase complex | details |
| TreatCFM001342 | intra-Golgi vesicle-mediated transport Nucleotide excision repair Basal transcription factors formation of glycosidic bonds, GlycosylTransferases: GTnc integral component of Golgi membrane | details |
| TreatCFM001400 | endoplasmic reticulum tubular network organization Group II intron splicing endoplasmic reticulum tubular network Basal transcription factors cytochrome complex assembly intra-Golgi vesicle-mediated transport integral component of Golgi membrane | details |
| TreatCFM001678 | Nucleotide excision repair Base excision repair beta-tubulin binding DNA-3-methyladenine glycosylase activity protein histidine kinase binding Group II intron splicing protein metabolic process tubulin complex assembly post-chaperonin tubulin folding pathway microtubule cytoskeleton organization base-excision repair cytochrome complex assembly GTPase activator activity positive regulation of GTPase activity | details |
| TreatCFM002098 | GDP-mannose biosynthesis L-ascorbate biosynthesis I (L-galactose pathway) Nucleotide excision repair biosynthetic process Fructose and mannose metabolism | details |
Expression profiles
 Show details about module gene expression profiling |