TreatCFM001962's detailed annotation
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Protein: Yellow color--query protein Green color--interaction proteins. Interaction line: Pink--proteins own interaction and positive co-expression relationship with target protein Blue--proteins own interaction and negative co-expression relationship with target protein Orange--proteins own interaction and protein-protein relationship with target protein |
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Module annotation (GSEA enrichment result)
| Function Annotation | FDR | Gene Ontolog |
|---|---|---|
| L-alpha-amino acid transmembrane transport | 0.006079583 | GO:1902475 |
| L-amino acid transport | 0.006079583 | GO:0015807 |
| hexose metabolic process | 0.006079583 | GO:0019318 |
| MicroRNAs in cancer | 0.007388104 | KEGG pathway |
| Thyroid hormone signaling pathway | 0.007388104 | KEGG pathway |
| Glycolysis / Gluconeogenesis | 0.011726464 | KEGG pathway |
| aldose 1-epimerase activity | 0.012161323 | GO:0004034 |
| early endosome membrane | 0.01349211 | GO:0031901 |
| L-amino acid transmembrane transporter activity | 0.015193569 | GO:0015179 |
| Transcription_related, Transcription factor: MYB | 0.018676529 | TF family |
| vesicle fusion | 0.023641112 | GO:0006906 |
| exocytosis | 0.023641112 | GO:0006887 |
| protein transport | 0.025232985 | GO:0015031 |
| SNAP receptor activity | 0.02955139 | GO:0005484 |
| SNARE binding | 0.02955139 | GO:0000149 |
| antiporter activity | 0.039311166 | GO:0015297 |
| carbohydrate binding | 0.043761682 | GO:0030246 |
Module member annotation
| Gene ID | Ortholog in Arabidopsis (Blast E-value) | Annotation in Arabidopsis |
|---|---|---|
| CRO_T013458 | AT1G58030 (9.00E-94) | CAT2|cationic amino acid transporter 2 |
| CRO_T014942 | AT3G17940 (4.00E-146) | Galactose mutarotase-like superfamily protein |
| CRO_T015565 | AT3G52250 (3.00E-07) | Duplicated homeodomain-like superfamily protein |
| CRO_T025801 | AT1G04760 (2.00E-102) | ATVAMP726|vesicle-associated membrane protein 726 |
| CRO_T026071 | AT3G09300 (0) | ORP3B|OSBP(oxysterol binding protein)-related protein 3B |
| CRO_T026129 | AT3G49890 (6.00E-29) | unknown protein |
| CRO_T032210 | AT4G18593 (5.00E-43) | dual specificity protein phosphatase-related |
Direct connection functional modules
| Module ID | Function Annotation | Overlap condition |
|---|---|---|
| TreatCFM001000 | recycling endosome Thyroid hormone signaling pathway Rab guanyl-nucleotide exchange factor activity formation of glycosidic bonds, GlycosylTransferases: GTnc Ubiquitin_Proteasome_system, E2: UBC Transcription_related, Transcription factor: MYB ubiquitin protein ligase binding cell wall organization positive regulation of GTPase activity protein ubiquitination transferase activity, transferring glycosyl groups ubiquitin protein ligase activity Golgi membrane | details |
| TreatCFM001079 | calcium-dependent cysteine-type endopeptidase activity formation of glycosidic bonds, GlycosylTransferases: GTnc Protein_kinases_phosphatases, PPC:1.3.1: Receptor-like protein kinase L-ornithine transmembrane transporter activity asparaginase activity L-histidine transmembrane transporter activity arginine transmembrane transporter activity sedoheptulose-bisphosphatase activity L-lysine transmembrane transporter activity early endosome membrane L-histidine transmembrane transport L-arginine import L-ornithine transmembrane transport arginine transmembrane transport L-lysine transmembrane transport proline biosynthetic process ascorbate glutathione cycle fructose 2,6-bisphosphate biosynthesis L-ascorbate degradation V L-asparagine degradation I ornithine-citrulline shuttle superpathway of aspartate and asparagine biosynthesis seed maturation proteolysis Ascorbate and aldarate metabolism sucrose biosynthesis I (from photosynthesis) Calvin-Benson-Bassham cycle RNA splicing seed germination Endocytosis | details |
| TreatCFM001184 | ornithine-citrulline shuttle Protein_kinases_phosphatases, PPC:1.3.1: Receptor-like protein kinase 26,27-dehydrozymosterol metabolism L-arginine biosynthesis I (via L-ornithine) L-ascorbate degradation V UMP biosynthesis I urea cycle Ascorbate and aldarate metabolism Pyrimidine metabolism arginine transmembrane transporter activity L-histidine transmembrane transporter activity L-ornithine transmembrane transporter activity early endosome membrane ascorbate glutathione cycle L-arginine biosynthesis II (acetyl cycle) L-glutamine degradation I L-lysine transmembrane transporter activity proline biosynthetic process L-arginine import L-lysine transmembrane transport arginine transmembrane transport L-ornithine transmembrane transport L-histidine transmembrane transport potassium ion transport seed maturation plant sterol biosynthesis nitrogen compound metabolic process seed germination solute:proton antiporter activity | details |
| TreatCFM001323 | L-asparagine degradation I formation of glycosidic bonds, GlycosylTransferases: GTnc superpathway of aspartate and asparagine biosynthesis early endosome membrane Apelin signaling pathway asparaginase activity autophagy cellular response to nitrogen starvation RNA splicing exocytosis vesicle fusion protein transport response to abscisic acid SNARE binding SNAP receptor activity ribosome binding Spliceosome chloroplast SNARE complex | details |
| TreatCFM001367 | superpathway of thiamine diphosphate biosynthesis III (eukaryotes) thiazole biosynthesis III (eukaryotes) rRNA base methylation thiazole biosynthetic process cellular response to DNA damage stimulus UDP-glucose metabolic process thiamine biosynthetic process tRNA methyltransferase activity UTP:glucose-1-phosphate uridylyltransferase activity UDP-glucose biosynthesis Thiamine metabolism rRNA methyltransferase activity stachyose degradation sucrose biosynthesis II tRNA methylation iron-sulfur cluster binding Pentose and glucuronate interconversions response to stress thylakoid cytoplasm cytosol stromule Protein_kinases_phosphatases, PPC:1.2.2: Receptor Like Cytoplasmic Kinase VII protein homodimerization activity | details |
| TreatCFM001393 | carbohydrate binding glucan 1,3-alpha-glucosidase activity aldose 1-epimerase activity L-amino acid transmembrane transporter activity solute:proton antiporter activity negative regulation of biological process L-alpha-amino acid transmembrane transport hexose metabolic process L-amino acid transport MicroRNAs in cancer early endosome membrane potassium ion transport Glycolysis / Gluconeogenesis N-Glycan biosynthesis SNARE binding SNAP receptor activity cellular macromolecule metabolic process antiporter activity primary metabolic process exocytosis vesicle fusion | details |
| TreatCFM001394 | benzoate biosynthesis III (CoA-dependent, non-β-oxidative) fatty acid α-oxidation I negative regulation of biological process L-alpha-amino acid transmembrane transport L-amino acid transport cellular aldehyde metabolic process mitochondrion organization integral component of mitochondrial outer membrane glucan 1,3-alpha-glucosidase activity aldehyde dehydrogenase [NAD(P)+] activity 3-chloroallyl aldehyde dehydrogenase activity MicroRNAs in cancer Mitophagy - animal L-amino acid transmembrane transporter activity Glycolysis / Gluconeogenesis cellular macromolecule metabolic process aldehyde dehydrogenase (NAD) activity N-Glycan biosynthesis primary metabolic process Ubiquitin_Proteasome_system, E3 adaptor: F-box small GTPase mediated signal transduction | details |
| TreatCFM001395 | MicroRNAs in cancer L-amino acid transmembrane transporter activity antiporter activity integral component of plasma membrane L-amino acid transport L-alpha-amino acid transmembrane transport hydrolysis and/or rearrangement of glycosidic bonds, Glycoside Hydrolases: GHnc amino acid transmembrane transport hydrolase activity, acting on ester bonds | details |
| TreatCFM001396 | MicroRNAs in cancer L-amino acid transport L-alpha-amino acid transmembrane transport L-amino acid transmembrane transporter activity response to stress antiporter activity | details |
| TreatCFM001449 | recycling endosome mannitol degradation II Thyroid hormone signaling pathway Rab guanyl-nucleotide exchange factor activity sinapyl alcohol dehydrogenase activity cinnamyl-alcohol dehydrogenase activity Protein_kinases_phosphatases, PPC:4.2.1: Calcium Dependent Protein Kinase Transcription_related, Transcription regulator: PHD calcium-dependent protein serine/threonine kinase activity zinc ion binding calmodulin-dependent protein kinase activity actin binding Phenylpropanoid biosynthesis regulation of stomatal movement actin filament organization peptidyl-serine phosphorylation protein autophosphorylation positive regulation of GTPase activity abscisic acid-activated signaling pathway calmodulin binding Transcription_related, Transcription factor: MYB | details |
| TreatCFM001492 | formation of glycosidic bonds, GlycosylTransferases: GTnc hydrolysis and/or rearrangement of glycosidic bonds, Glycoside Hydrolases: GHnc alpha-1,3-mannosyltransferase activity galactoside 2-alpha-L-fucosyltransferase activity mannosylglycoprotein endo-beta-mannosidase activity ceramide metabolic process L-amino acid transport fucosylation nucleocytoplasmic transport xyloglucan biosynthetic process mannosylation L-alpha-amino acid transmembrane transport hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides plant-type cell wall biogenesis fatty acid β-oxidation II (peroxisome) protein N-glycosylation (eukaryotic, high mannose) unsaturated, even numbered fatty acid β-oxidation L-amino acid transmembrane transporter activity MicroRNAs in cancer translation | details |
| TreatCFM001589 | 4-hydroxy-4-methyl-L-glutamate biosynthesis N-acetylgalactosamine kinase activity galactokinase activity 2'-deoxymugineic acid phytosiderophore biosynthesis D-galactose degradation III nucleomorph stachyose degradation late endosome RNA polymerase II activity retromer complex DNA-directed RNA polymerase II, core complex transcription from RNA polymerase II promoter retrograde transport, endosome to Golgi galactose metabolic process carbohydrate phosphorylation | details |
| TreatCFM001726 | L-phenylalanine biosynthesis II L-tyrosine biosynthesis II Transcription_related, Transcription factor: Whirly hydrolysis and/or rearrangement of glycosidic bonds, Glycoside Hydrolases: GHnc MicroRNAs in cancer L-amino acid transport chorismate metabolic process L-alpha-amino acid transmembrane transport Ubiquitin_Proteasome_system, DUB: USP aromatic amino acid family biosynthetic process chorismate mutase activity defense response to fungus cellular protein metabolic process L-amino acid transmembrane transporter activity cysteine-type peptidase activity positive regulation of transcription, DNA-templated Biosynthesis of amino acids antiporter activity hydrolase activity, acting on ester bonds | details |
| TreatCFM001783 | Protein_kinases_phosphatases, PPC:4.5.8: Unknown Function Kinase Thyroid hormone signaling pathway Protein_kinases_phosphatases, PPC:4.2.1: Calcium Dependent Protein Kinase Transcription_related, Transcription factor: MYB regulation of stomatal movement actin filament organization calcium-dependent protein serine/threonine kinase activity actin binding calmodulin-dependent protein kinase activity | details |
| TreatCFM001821 | mRNA splicing, via spliceosome Spliceosome Transcription_related, Transcription factor: Whirly MicroRNAs in cancer hydrolysis and/or rearrangement of glycosidic bonds, Glycoside Hydrolases: GHnc DNA replication factor A complex L-amino acid transport L-alpha-amino acid transmembrane transport Ubiquitin_Proteasome_system, DUB: USP Prp19 complex Cul4-RING E3 ubiquitin ligase complex COPII vesicle coat Proteasome precatalytic spliceosome catalytic step 2 spliceosome defense response to fungus regulation of gene expression RNA secondary structure unwinding ER to Golgi vesicle-mediated transport cellular protein metabolic process positive regulation of transcription, DNA-templated | details |
| TreatCFM001892 | Transcription_related, Transcription factor: NF-X1 Human papillomavirus infection Thyroid hormone signaling pathway response to light intensity salicylic acid biosynthetic process hexose metabolic process response to microbial phytotoxin regulation of hydrogen peroxide metabolic process regulation of stomatal movement Glycolysis / Gluconeogenesis actin filament organization aldose 1-epimerase activity Transcription_related, Transcription factor: MYB response to salt stress defense response to bacterium | details |
| TreatCFM002074 | proteolysis L-alpha-amino acid transmembrane transport L-amino acid transport Ubiquitin_Proteasome_system, DUB: USP MicroRNAs in cancer cellular protein metabolic process cysteine-type peptidase activity L-amino acid transmembrane transporter activity metal ion binding aspartic-type endopeptidase activity antiporter activity | details |
| TreatCFM002143 | cytosol Sec61 translocon complex aldose 1-epimerase activity intracellular transport hexose metabolic process positive regulation of G2/M transition of mitotic cell cycle cullin deneddylation COP9 signalosome membrane coat Thyroid hormone signaling pathway proteasome complex Transcription_related, Transcription factor: MYB Glycolysis / Gluconeogenesis Lysosome Protein export protein transporter activity | details |
Expression profiles
 Show details about module gene expression profiling |