TreatCFM000254's detailed annotation
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Protein: Yellow color--query protein Green color--interaction proteins. Interaction line: Pink--proteins own interaction and positive co-expression relationship with target protein Blue--proteins own interaction and negative co-expression relationship with target protein Orange--proteins own interaction and protein-protein relationship with target protein |
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Module annotation (GSEA enrichment result)
| Function Annotation | FDR | Gene Ontolog |
|---|---|---|
| Amyotrophic lateral sclerosis (ALS) | 0.000531915 | KEGG pathway |
| Transcription_related, Transcription regulator: SWI/SNF-SWI3 | 0.000886394 | TF family |
| mitochondrial outer membrane translocase complex | 0.001063594 | GO:0005742 |
| spermine and spermidine degradation III | 0.002303262 | plantCyc |
| histone H3-K4 methylation | 0.004875166 | GO:0051568 |
| protein import into mitochondrial matrix | 0.007307347 | GO:0030150 |
| protein channel activity | 0.024274631 | GO:0015266 |
Module member annotation
| Gene ID | Ortholog in Arabidopsis (Blast E-value) | Annotation in Arabidopsis |
|---|---|---|
| CRO_T001214 | AT1G05410 (7.00E-88) | Protein of unknown function (DUF1423) |
| CRO_T008137 | AT3G20000 (5.00E-110) | TOM40|translocase of the outer mitochondrial membrane 40 |
| CRO_T009684 | AT1G62830 (0) | ATLSD1|ARABIDOPSIS LYSINE-SPECIFIC HISTONE DEMETHYLASE; LDL1|LSD1-like 1; LSD1|LYSINE-SPECIFIC HISTONE DEMETHYLASE |
| CRO_T014904 | AT4G26000 (4.00E-78) | PEP|PEPPER |
| CRO_T016536 | AT5G48830 (8.00E-99) | unknown protein |
| CRO_T026964 | AT3G18380 (8.00E-39) | DTF2|DNA-BINDING TRANSCRIPTION FACTOR 2; SHH2|SAWADEE homeodomain homolog 2 |
Direct connection functional modules
| Module ID | Function Annotation | Overlap condition |
|---|---|---|
| TreatCFM000096 | Protein_kinases_phosphatases, PPC:1.4.1: Crinkly 4 Like Kinase DNA ligation involved in DNA repair double-strand break repair via nonhomologous end joining lagging strand elongation protein ADP-ribosylation nucleic acid binding hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances NAD+ ADP-ribosyltransferase activity DNA ligase (ATP) activity adenosine ribonucleotides de novo biosynthesis Base excision repair NF-kappa B signaling pathway | details |
| TreatCFM000131 | post-embryonic root development U5 snRNA 3'-end processing exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nuclear polyadenylation-dependent mRNA catabolic process nuclear polyadenylation-dependent tRNA catabolic process U1 snRNA 3'-end processing nuclear polyadenylation-dependent rRNA catabolic process nuclear mRNA surveillance nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U4 snRNA 3'-end processing MAPK signaling pathway - yeast AU-rich element binding protein domain specific binding cytoplasmic exosome (RNase complex) nuclear exosome (RNase complex) RNA degradation Transcription_related, Transcription factor: HB | details |
| TreatCFM000208 | adenosine ribonucleotides de novo biosynthesis Golgi apparatus cell division site cell plate plant-type vacuole nuclear envelope cytokinesis by cell plate formation nucleic acid binding O-acetyltransferase activity cell wall organization or biogenesis | details |
| TreatCFM000637 | Amyotrophic lateral sclerosis (ALS) mitochondrial outer membrane translocase complex protein import into mitochondrial matrix vacuolar transport NLS-bearing protein import into nucleus base-excision repair DNA N-glycosylase activity nucleoplasm nuclear pore Base excision repair Lysosome regulation of catalytic activity nuclear localization sequence binding protein channel activity cysteine-type endopeptidase activity protein transporter activity Endocytosis | details |
| TreatCFM001161 | Transcription_related, Transcription regulator: LIM glycolysis I (from glucose 6-phosphate) Transcription_related, Transcription factor: C2H2 | details |
| TreatCFM001242 | DNA replication, synthesis of RNA primer primosome complex DNA primase activity Cell cycle 4 iron, 4 sulfur cluster binding | details |
| TreatCFM001292 | Transcription_related, Transcription regulator: SWI/SNF-SWI3 spermine and spermidine degradation III starch biosynthesis regulation of SNARE complex assembly lysosome organization histone H3-K4 methylation endosome organization glycogen biosynthetic process transcription from RNA polymerase III promoter vesicle docking involved in exocytosis clathrin vesicle coat HOPS complex protein binding, bridging glucose-1-phosphate adenylyltransferase activity starch biosynthetic process DNA-directed RNA polymerase III complex RNA polymerase III activity ribonucleoside binding ATP-dependent peptidase activity DNA binding Autophagy - yeast | details |
| TreatCFM001378 | protein import into nucleus, docking protein import into nucleus, translocation cellular response to nitrogen starvation ribosomal protein import into nucleus Mismatch repair clathrin vesicle coat mismatch repair complex NLS-bearing protein import into nucleus autophagy nuclear membrane nuclear periphery Transcription_related, Transcription factor: MYB Apelin signaling pathway Phenylpropanoid biosynthesis very long chain fatty acid biosynthesis I very long chain fatty acid biosynthesis II Fatty acid metabolism Ran GTPase binding nuclear localization sequence binding mismatched DNA binding | details |
| TreatCFM001380 | Fanconi anemia pathway Pyrimidine metabolism pollen exine formation pyrimidine nucleotide biosynthetic process 'de novo' pyrimidine nucleobase biosynthetic process nucleotide phosphorylation CMP phosphorylation pyrimidine deoxyribonucleotide phosphorylation UTP and CTP de novo biosynthesis cytidylate kinase activity uridylate kinase activity adhesion to carbohydrates, Carbohydrate-Binding Modules: CBM57 hydrolysis and/or rearrangement of glycosidic bonds, Glycoside Hydrolases: GHnc adenosine ribonucleotides de novo biosynthesis pyrimidine ribonucleotides interconversion | details |
| TreatCFM001381 | vacuolar transport Arachidonic acid metabolism Fanconi anemia pathway Endocytosis | details |
| TreatCFM001410 | polyamine transmembrane transport mitotic spindle assembly checkpoint Transcription_related, Transcription factor: bZIP cellular metabolic process amino acid transmembrane transport L-amino acid transmembrane transporter activity polyamine transmembrane transporter activity Cell cycle | details |
| TreatCFM001465 | proteolysis response to reactive oxygen species regulation of gene expression methylated histone binding AMPK signaling pathway Cell cycle - Caulobacter translational elongation Transcription_related, Transcription regulator: TRAF Ubiquitin_Proteasome_system, E3 adaptor: BTB ATP-dependent peptidase activity translation elongation factor activity | details |
| TreatCFM001801 | positive regulation of transport RNA binding protein binding involved in protein folding Ribosome biogenesis in eukaryotes tRNA processing rRNA processing unfolded protein binding | details |
| TreatCFM001888 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity 3'-phospho-5'-adenylyl sulfate transmembrane transport Transcription_related, Transcription regulator: TRAF integral component of Golgi membrane clathrin vesicle coat integral component of endoplasmic reticulum membrane ATP-dependent peptidase activity Ubiquitin_Proteasome_system, E3 adaptor: BTB carbohydrate transport Plant hormone signal transduction vesicle-mediated transport endomembrane system | details |
| TreatCFM002029 | Transcription_related, Transcription regulator: TRAF Ubiquitin_Proteasome_system, E3 adaptor: BTB Plant hormone signal transduction Spliceosome | details |
Expression profiles
 Show details about module gene expression profiling |