TreatCFM001378's detailed annotation
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Protein: Yellow color--query protein Green color--interaction proteins. Interaction line: Pink--proteins own interaction and positive co-expression relationship with target protein Blue--proteins own interaction and negative co-expression relationship with target protein Orange--proteins own interaction and protein-protein relationship with target protein |
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Module annotation (GSEA enrichment result)
| Function Annotation | FDR | Gene Ontolog |
|---|---|---|
| protein import into nucleus, docking | 0.013529332 | GO:0000059 |
| protein import into nucleus, translocation | 0.013529332 | GO:0000060 |
| cellular response to nitrogen starvation | 0.013529332 | GO:0006995 |
| ribosomal protein import into nucleus | 0.013529332 | GO:0006610 |
| Mismatch repair | 0.013529332 | KEGG pathway |
| clathrin vesicle coat | 0.014450706 | GO:0030125 |
| mismatch repair complex | 0.014450706 | GO:0032300 |
| NLS-bearing protein import into nucleus | 0.015451132 | GO:0006607 |
| autophagy | 0.015451132 | GO:0006914 |
| nuclear membrane | 0.015884507 | GO:0031965 |
| nuclear periphery | 0.015884507 | GO:0034399 |
| Transcription_related, Transcription factor: MYB | 0.023947625 | TF family |
| Apelin signaling pathway | 0.025422901 | KEGG pathway |
| Phenylpropanoid biosynthesis | 0.032896558 | KEGG pathway |
| very long chain fatty acid biosynthesis I | 0.032896558 | plantCyc |
| very long chain fatty acid biosynthesis II | 0.032896558 | plantCyc |
| Fatty acid metabolism | 0.044020918 | KEGG pathway |
| Ran GTPase binding | 0.049537245 | GO:0008536 |
| nuclear localization sequence binding | 0.049537245 | GO:0008139 |
| mismatched DNA binding | 0.049537245 | GO:0030983 |
Module member annotation
| Gene ID | Ortholog in Arabidopsis (Blast E-value) | Annotation in Arabidopsis |
|---|---|---|
| CRO_T001551 | AT3G08943 (5.00E-63) | ARM repeat superfamily protein |
| CRO_T002856 | AT2G40060 (2.00E-18) | CLC2|clathrin light chain 2 |
| CRO_T006601 | AT4G32720 (6.00E-95) | AtLa1|La protein 1 |
| CRO_T011094 | AT3G47360 (1.00E-12) | ATHSD3|HYDROXYSTEROID DEHYDROGENASE 3 |
| CRO_T016067 | AT3G15580 (3.00E-43) | APG8H|AUTOPHAGY 8H; ATG8I|AUTOPHAGY 8I |
| CRO_T016536 | AT5G48830 (8.00E-99) | unknown protein |
| CRO_T018601 | AT2G33590 (8.00E-114) | CRL1|CCR(Cinnamoyl coA:NADP oxidoreductase)-like 1 |
| CRO_T023342 | AT2G32170 (2.00E-04) | S-adenosyl-L-methionine-dependent methyltransferases superfamily protein |
| CRO_T032977 | AT3G18524 (0) | MSH2|MUTS homolog 2 |
Direct connection functional modules
| Module ID | Function Annotation | Overlap condition |
|---|---|---|
| TreatCFM000064 | clathrin vesicle coat secologanin and strictosidine biosynthesis Transcription_related, Transcription factor: NAC | details |
| TreatCFM000094 | Transcription_related, Transcription regulator: MED6 D-myo-inositol (1,4,5)-trisphosphate degradation ethylene biosynthesis I (plants) L-methionine salvage cycle II (plants) | details |
| TreatCFM000254 | Amyotrophic lateral sclerosis (ALS) Transcription_related, Transcription regulator: SWI/SNF-SWI3 mitochondrial outer membrane translocase complex spermine and spermidine degradation III histone H3-K4 methylation protein import into mitochondrial matrix protein channel activity | details |
| TreatCFM000413 | Mitophagy - animal clathrin vesicle coat Fatty acid metabolism Phenylpropanoid biosynthesis very long chain fatty acid biosynthesis I very long chain fatty acid biosynthesis II vesicle-mediated transport | details |
| TreatCFM000442 | cullin deneddylation Ubiquitin_Proteasome_system, DUB: JAMM COP9 signalosome Phenylpropanoid biosynthesis intracellular part ATP-dependent helicase activity coenzyme binding | details |
| TreatCFM000914 | Transcription_related, Transcription factor: CPP mismatch repair complex Mismatch repair Transcription_related, Transcription regulator: SNF2 Mitophagy - animal mismatched DNA binding serine-type peptidase activity very long chain fatty acid biosynthesis I very long chain fatty acid biosynthesis II Fatty acid metabolism Homologous recombination | details |
| TreatCFM000964 | cullin deneddylation COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM Phenylpropanoid biosynthesis coenzyme binding | details |
| TreatCFM001020 | long-chain fatty acid-CoA ligase activity FAD binding clathrin vesicle coat Fatty acid metabolism Transcription_related, Transcription factor: HB long-chain fatty acid metabolic process cutin biosynthesis fatty acid β-oxidation II (peroxisome) long-chain fatty acid activation oleate biosynthesis I (plants) palmitate biosynthesis II (bacteria and plants) phosphatidylcholine acyl editing sporopollenin precursors biosynthesis stearate biosynthesis II (bacteria and plants) suberin monomers biosynthesis | details |
| TreatCFM001137 | Apelin signaling pathway Transcription_related, Transcription regulator: GNAT cellular response to nitrogen starvation N-terminal protein amino acid acetylation autophagy protein acetyltransferase complex intracellular part ATP-dependent helicase activity peptide alpha-N-acetyltransferase activity | details |
| TreatCFM001206 | Ubiquitin_Proteasome_system, DUB: JAMM cullin deneddylation COP9 signalosome nitrogen compound metabolic process hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Phenylpropanoid biosynthesis plastid coenzyme binding transferase activity, transferring acyl groups | details |
| TreatCFM001292 | Transcription_related, Transcription regulator: SWI/SNF-SWI3 spermine and spermidine degradation III starch biosynthesis regulation of SNARE complex assembly lysosome organization histone H3-K4 methylation endosome organization glycogen biosynthetic process transcription from RNA polymerase III promoter vesicle docking involved in exocytosis clathrin vesicle coat HOPS complex protein binding, bridging glucose-1-phosphate adenylyltransferase activity starch biosynthetic process DNA-directed RNA polymerase III complex RNA polymerase III activity ribonucleoside binding ATP-dependent peptidase activity DNA binding Autophagy - yeast | details |
| TreatCFM001417 | Transcription_related, Transcription regulator: GNAT Ctf18 RFC-like complex ribonucleoside-diphosphate reductase complex chromosome, centromeric region chromatin maintenance of mitotic sister chromatid cohesion protein acetyltransferase complex deoxyribonucleotide biosynthetic process cellular response to nitrogen starvation regulation of DNA replication DNA clamp loader activity ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor nucleoplasm peptide alpha-N-acetyltransferase activity Apelin signaling pathway autophagy N-terminal protein amino acid acetylation DNA replication protein binding Purine metabolism | details |
| TreatCFM001418 | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Transcription_related, Transcription factor: CPP serine-type peptidase activity Transcription_related, Transcription factor: C2H2 Transcription_related, Transcription factor: MYB proteolysis | details |
| TreatCFM001465 | proteolysis response to reactive oxygen species regulation of gene expression methylated histone binding AMPK signaling pathway Cell cycle - Caulobacter translational elongation Transcription_related, Transcription regulator: TRAF Ubiquitin_Proteasome_system, E3 adaptor: BTB ATP-dependent peptidase activity translation elongation factor activity | details |
| TreatCFM001596 | chlorophyll cycle chlorophyll synthetase activity Porphyrin and chlorophyll metabolism chlorophyll biosynthetic process clathrin vesicle coat vesicle-mediated transport transferase activity, transferring glycosyl groups | details |
| TreatCFM001801 | positive regulation of transport RNA binding protein binding involved in protein folding Ribosome biogenesis in eukaryotes tRNA processing rRNA processing unfolded protein binding | details |
| TreatCFM001888 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity 3'-phospho-5'-adenylyl sulfate transmembrane transport Transcription_related, Transcription regulator: TRAF integral component of Golgi membrane clathrin vesicle coat integral component of endoplasmic reticulum membrane ATP-dependent peptidase activity Ubiquitin_Proteasome_system, E3 adaptor: BTB carbohydrate transport Plant hormone signal transduction vesicle-mediated transport endomembrane system | details |
| TreatCFM001901 | Ubiquitin_Proteasome_system, E3 adaptor: DDB1 DNA replication proofreading nucleotide-excision repair, DNA gap filling base-excision repair, gap-filling Mitophagy - animal clathrin vesicle coat delta DNA polymerase complex nucleotide-excision repair red, far-red light phototransduction 3'-5'-exodeoxyribonuclease activity Phenylpropanoid biosynthesis cullin-RING ubiquitin ligase complex DNA biosynthetic process DNA-directed DNA polymerase activity damaged DNA binding coenzyme binding proteasome-mediated ubiquitin-dependent protein catabolic process nucleic acid phosphodiester bond hydrolysis vesicle-mediated transport | details |
Expression profiles
 Show details about module gene expression profiling |