TreatCFM000637's detailed annotation
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Protein: Yellow color--query protein Green color--interaction proteins. Interaction line: Pink--proteins own interaction and positive co-expression relationship with target protein Blue--proteins own interaction and negative co-expression relationship with target protein Orange--proteins own interaction and protein-protein relationship with target protein |
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Module annotation (GSEA enrichment result)
| Function Annotation | FDR | Gene Ontolog |
|---|---|---|
| Amyotrophic lateral sclerosis (ALS) | 0.005171089 | KEGG pathway |
| mitochondrial outer membrane translocase complex | 0.014165016 | GO:0005742 |
| protein import into mitochondrial matrix | 0.015180105 | GO:0030150 |
| vacuolar transport | 0.015180105 | GO:0007034 |
| NLS-bearing protein import into nucleus | 0.015180105 | GO:0006607 |
| base-excision repair | 0.015180105 | GO:0006284 |
| DNA N-glycosylase activity | 0.018767725 | GO:0019104 |
| nucleoplasm | 0.020424331 | GO:0005654 |
| nuclear pore | 0.020424331 | GO:0005643 |
| Base excision repair | 0.020623931 | KEGG pathway |
| Lysosome | 0.020623931 | KEGG pathway |
| regulation of catalytic activity | 0.022432724 | GO:0050790 |
| nuclear localization sequence binding | 0.022495327 | GO:0008139 |
| protein channel activity | 0.022495327 | GO:0015266 |
| cysteine-type endopeptidase activity | 0.029956567 | GO:0004197 |
| protein transporter activity | 0.038130356 | GO:0008565 |
| Endocytosis | 0.042723545 | KEGG pathway |
Module member annotation
| Gene ID | Ortholog in Arabidopsis (Blast E-value) | Annotation in Arabidopsis |
|---|---|---|
| CRO_T002962 | AT3G05720 (2.00E-14) | IMPA-7|importin alpha isoform 7 |
| CRO_T008137 | AT3G20000 (5.00E-110) | TOM40|translocase of the outer mitochondrial membrane 40 |
| CRO_T013317 | AT3G45310 (1.00E-16) | Cysteine proteinases superfamily protein |
| CRO_T014904 | AT4G26000 (4.00E-78) | PEP|PEPPER |
| CRO_T020572 | AT1G03950 (5.00E-76) | VPS2.3|vacuolar protein sorting-associated protein 2.3 |
| CRO_T023722 | AT2G40600 (4.00E-38) | appr-1-p processing enzyme family protein |
| CRO_T031785 | AT4G12740 (5.00E-130) | HhH-GPD base excision DNA repair family protein |
Direct connection functional modules
| Module ID | Function Annotation | Overlap condition |
|---|---|---|
| TreatCFM000028 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds vacuolar proton-transporting V-type ATPase complex assembly nitrogen compound metabolic process retrograde transport, endosome to Golgi endoplasmic reticulum-Golgi intermediate compartment membrane | details |
| TreatCFM000096 | Protein_kinases_phosphatases, PPC:1.4.1: Crinkly 4 Like Kinase DNA ligation involved in DNA repair double-strand break repair via nonhomologous end joining lagging strand elongation protein ADP-ribosylation nucleic acid binding hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances NAD+ ADP-ribosyltransferase activity DNA ligase (ATP) activity adenosine ribonucleotides de novo biosynthesis Base excision repair NF-kappa B signaling pathway | details |
| TreatCFM000131 | post-embryonic root development U5 snRNA 3'-end processing exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nuclear polyadenylation-dependent mRNA catabolic process nuclear polyadenylation-dependent tRNA catabolic process U1 snRNA 3'-end processing nuclear polyadenylation-dependent rRNA catabolic process nuclear mRNA surveillance nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U4 snRNA 3'-end processing MAPK signaling pathway - yeast AU-rich element binding protein domain specific binding cytoplasmic exosome (RNase complex) nuclear exosome (RNase complex) RNA degradation Transcription_related, Transcription factor: HB | details |
| TreatCFM000182 | trans-zeatin biosynthesis | details |
| TreatCFM000208 | adenosine ribonucleotides de novo biosynthesis Golgi apparatus cell division site cell plate plant-type vacuole nuclear envelope cytokinesis by cell plate formation nucleic acid binding O-acetyltransferase activity cell wall organization or biogenesis | details |
| TreatCFM000254 | Amyotrophic lateral sclerosis (ALS) Transcription_related, Transcription regulator: SWI/SNF-SWI3 mitochondrial outer membrane translocase complex spermine and spermidine degradation III histone H3-K4 methylation protein import into mitochondrial matrix protein channel activity | details |
| TreatCFM000340 | details | |
| TreatCFM000467 | vacuolar transport Endocytosis intracellular | details |
| TreatCFM000516 | intracellular fucose biosynthetic process xyloglucan biosynthetic process endomembrane system organization formation of glycosidic bonds, GlycosylTransferases: GTnc integral component of Golgi membrane | details |
| TreatCFM000533 | PI3K-Akt signaling pathway Transcription_related, Transcription factor: CAMTA TORC1 complex TOR signaling organophosphate ester transport organic phosphonate transport transmembrane transport plasma membrane | details |
| TreatCFM000538 | vacuolar transport Transcription_related, Transcription factor: NF-YC protein heterodimerization activity Antigen processing and presentation Endocytosis | details |
| TreatCFM000618 | dUDP biosynthetic process dTDP biosynthetic process dTTP biosynthetic process thymidylate kinase activity ethanolamine-phosphate cytidylyltransferase activity | details |
| TreatCFM000706 | vacuolar transport Endocytosis | details |
| TreatCFM000788 | vacuolar transport Endocytosis intracellular | details |
| TreatCFM000974 | Protein_kinases_phosphatases, PPC:4.1.4: MAP2K defense response, incompatible interaction activation of MAPK activity indole-3-acetyl-amide conjugate biosynthesis vacuolar transport MAP kinase kinase activity | details |
| TreatCFM001029 | vacuolar transport Endocytosis intracellular | details |
| TreatCFM001123 | vacuolar transport Endocytosis intracellular | details |
| TreatCFM001161 | Transcription_related, Transcription regulator: LIM glycolysis I (from glucose 6-phosphate) Transcription_related, Transcription factor: C2H2 | details |
| TreatCFM001208 | vacuolar transport Protein_kinases_phosphatases, PPC:4.4.1: Unknown Function Kinase Endocytosis intracellular | details |
| TreatCFM001242 | DNA replication, synthesis of RNA primer primosome complex DNA primase activity Cell cycle 4 iron, 4 sulfur cluster binding | details |
| TreatCFM001272 | phosphatidylethanolamine biosynthesis II ethanolamine-phosphate cytidylyltransferase activity peptide metabolic process Noc complex integral component of mitochondrial outer membrane nuclear lumen | details |
| TreatCFM001310 | L-cysteine biosynthesis I transmembrane transport cysteine biosynthetic process from serine organophosphate ester transport organic phosphonate transport Ascorbate and aldarate metabolism cytoplasm plasma membrane cellular amino acid biosynthetic process monodehydroascorbate reductase (NADH) activity organic phosphonate transmembrane-transporting ATPase activity cysteine synthase activity cell redox homeostasis | details |
| TreatCFM001380 | Fanconi anemia pathway Pyrimidine metabolism pollen exine formation pyrimidine nucleotide biosynthetic process 'de novo' pyrimidine nucleobase biosynthetic process nucleotide phosphorylation CMP phosphorylation pyrimidine deoxyribonucleotide phosphorylation UTP and CTP de novo biosynthesis cytidylate kinase activity uridylate kinase activity adhesion to carbohydrates, Carbohydrate-Binding Modules: CBM57 hydrolysis and/or rearrangement of glycosidic bonds, Glycoside Hydrolases: GHnc adenosine ribonucleotides de novo biosynthesis pyrimidine ribonucleotides interconversion | details |
| TreatCFM001381 | vacuolar transport Arachidonic acid metabolism Fanconi anemia pathway Endocytosis | details |
| TreatCFM001410 | polyamine transmembrane transport mitotic spindle assembly checkpoint Transcription_related, Transcription factor: bZIP cellular metabolic process amino acid transmembrane transport L-amino acid transmembrane transporter activity polyamine transmembrane transporter activity Cell cycle | details |
| TreatCFM001555 | vacuolar transport Transcription_related, Transcription factor: HB intracellular | details |
| TreatCFM001888 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity 3'-phospho-5'-adenylyl sulfate transmembrane transport Transcription_related, Transcription regulator: TRAF integral component of Golgi membrane clathrin vesicle coat integral component of endoplasmic reticulum membrane ATP-dependent peptidase activity Ubiquitin_Proteasome_system, E3 adaptor: BTB carbohydrate transport Plant hormone signal transduction vesicle-mediated transport endomembrane system | details |
| TreatCFM001974 | fatty acid biosynthesis (plant mitochondria) anthocyanidin modification (Arabidopsis) ubiquitin-protein transferase activator activity anaphase-promoting complex binding Fatty acid metabolism Ubiquitin mediated proteolysis flavonoid biosynthetic process flavonoid glucuronidation regulation of catalytic activity fatty acid biosynthetic process cell division | details |
| TreatCFM002029 | Transcription_related, Transcription regulator: TRAF Ubiquitin_Proteasome_system, E3 adaptor: BTB Plant hormone signal transduction Spliceosome | details |
| TreatCFM002076 | eukaryotic translation initiation factor 2B complex SCF ubiquitin ligase complex proteasome complex S-methyl-5-thioribose-1-phosphate isomerase activity myosin heavy chain kinase activity guanyl-nucleotide exchange factor activity simple leaf morphogenesis regulation of auxin mediated signaling pathway L-methionine biosynthetic process from methylthioadenosine SCF-dependent proteasomal ubiquitin-dependent protein catabolic process leaf vascular tissue pattern formation Fanconi anemia pathway Proteasome regulation of translational initiation positive regulation of GTPase activity translational initiation RNA transport translation initiation factor activity 2-alkenal reductase [NAD(P)] activity | details |
| TreatCFM002115 | 2-alkenal reductase [NAD(P)] activity anthocyanidin modification (Arabidopsis) proteasome complex Proteasome Transcription_related, Transcription factor: bZIP Transcription_related, Transcription factor: C2H2 | details |
| TreatCFM002128 | anthocyanidin modification (Arabidopsis) Herpes simplex infection Fanconi anemia pathway ether hydrolase activity myosin heavy chain kinase activity | details |
Expression profiles
 Show details about module gene expression profiling |