TreatCFM000613's detailed annotation
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Protein: Yellow color--query protein Green color--interaction proteins. Interaction line: Pink--proteins own interaction and positive co-expression relationship with target protein Blue--proteins own interaction and negative co-expression relationship with target protein Orange--proteins own interaction and protein-protein relationship with target protein |
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Module annotation (GSEA enrichment result)
| Function Annotation | FDR | Gene Ontolog |
|---|---|---|
| Ubiquitin_Proteasome_system, DUB: JAMM | 1.01E-05 | ubs family |
| proteasome complex | 0.012477854 | GO:0000502 |
| precatalytic spliceosome | 0.012477854 | GO:0071011 |
| COP9 signalosome | 0.012477854 | GO:0008180 |
| cullin deneddylation | 0.014287815 | GO:0010388 |
| proteasome-mediated ubiquitin-dependent protein catabolic process | 0.033688969 | GO:0043161 |
| response to salt stress | 0.033688969 | GO:0009651 |
| Proteasome | 0.044561049 | KEGG pathway |
Module member annotation
| Gene ID | Ortholog in Arabidopsis (Blast E-value) | Annotation in Arabidopsis |
|---|---|---|
| CRO_T000451 | - | - |
| CRO_T003215 | - | - |
| CRO_T007577 | AT2G31600 (5.00E-32) | unknown protein |
| CRO_T009781 | - | - |
| CRO_T012733 | AT4G26430 (7.00E-134) | CSN6B|COP9 signalosome subunit 6B |
| CRO_T014504 | - | - |
| CRO_T020964 | AT2G44420 (1.00E-88) | protein N-terminal asparagine amidohydrolase family protein |
| CRO_T024606 | - | - |
| CRO_T024756 | - | - |
| CRO_T027212 | AT5G37370 (1.00E-46) | ATSRL1|PRP38 family protein |
| CRO_T033225 | AT3G11270 (4.00E-157) | MEE34|maternal effect embryo arrest 34 |
Direct connection functional modules
| Module ID | Function Annotation | Overlap condition |
|---|---|---|
| TreatCFM000017 | Oxidative phosphorylation mitochondrion NADH dehydrogenase (ubiquinone) activity mitochondrial inner membrane heme transporter activity heme transport cytochrome-c oxidase activity respiratory chain cytochrome complex assembly hydrogen ion transmembrane transport ATP synthesis coupled electron transport heme binding aerobic respiration hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances aerobic electron transport chain electron transport chain generation of precursor metabolites and energy ATP synthesis coupled proton transport mitochondrial electron transport, NADH to ubiquinone hydrogen ion transmembrane transporter activity quinone binding photosynthetic electron transport in photosystem II succinate dehydrogenase activity electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity succinate dehydrogenase complex | details |
| TreatCFM000026 | Ubiquitin_Proteasome_system, DUB: JAMM Proteasome carbohydrate transport proteasome-mediated ubiquitin-dependent protein catabolic process proteasome complex | details |
| TreatCFM000032 | details | |
| TreatCFM000046 | details | |
| TreatCFM000065 | Cytochrome_P450, Cytochrome P450: CYP724A | details |
| TreatCFM000073 | cullin deneddylation COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM Oxidative phosphorylation | details |
| TreatCFM000076 | Protein_kinases_phosphatases, PPC:4.1.4: MAP2K Ubiquitin_Proteasome_system, DUB: JAMM defense response, incompatible interaction histone modification activation of MAPK activity transcription elongation from RNA polymerase II promoter cullin deneddylation COP9 signalosome Cdc73/Paf1 complex MAP kinase kinase activity MAP kinase activity transcription coactivator activity transcription from RNA polymerase II promoter MAPK cascade MAPK signaling pathway - plant | details |
| TreatCFM000078 | proteasome complex Transcription_related, Transcription factor: GeBP Ubiquitin_Proteasome_system, DUB: JAMM Proteasome Transcription_related, Transcription factor: Trihelix proteasome-mediated ubiquitin-dependent protein catabolic process | details |
| TreatCFM000099 | Spliceosome sulfate activation for sulfonation sulfate reduction II (assimilatory) Transcription_related, Transcription factor: NAC Ubiquitin_Proteasome_system, DUB: JAMM HTLV-I infection L-valine degradation I | details |
| TreatCFM000118 | Ubiquitin_Proteasome_system, DUB: JAMM formation of glycosidic bonds, GlycosylTransferases: GTnc | details |
| TreatCFM000122 | 3-hydroxyisobutyryl-CoA hydrolase activity L-valine degradation I histone acetyltransferase activity heterotrimeric G-protein complex Cul4-RING E3 ubiquitin ligase complex organ morphogenesis regulation of root development lateral root development fruit development defense response to fungus, incompatible interaction response to extracellular stimulus endoplasmic reticulum unfolded protein response reactive oxygen species metabolic process negative regulation of abscisic acid-activated signaling pathway Ras signaling pathway histone acetylation jasmonic acid mediated signaling pathway Transcription_related, Transcription regulator: mTERF response to ethylene | details |
| TreatCFM000126 | Ubiquitin_Proteasome_system, DUB: JAMM proteasome complex Proteasome proteasome-mediated ubiquitin-dependent protein catabolic process | details |
| TreatCFM000178 | cell tip growth mitotic spindle assembly checkpoint | details |
| TreatCFM000182 | trans-zeatin biosynthesis | details |
| TreatCFM000183 | calcium ion transport Ubiquitin_Proteasome_system, DUB: JAMM Proteasome proteasome-mediated ubiquitin-dependent protein catabolic process proteasome complex | details |
| TreatCFM000207 | proteasome complex xylogalacturonan biosynthesis Ubiquitin_Proteasome_system, DUB: JAMM Proteasome formation of glycosidic bonds, GlycosylTransferases: GTnc proteasome-mediated ubiquitin-dependent protein catabolic process transferase activity | details |
| TreatCFM000209 | intracellular Ubiquitin_Proteasome_system, DUB: OTU | details |
| TreatCFM000214 | tubulin binding formation of glycosidic bonds, GlycosylTransferases: GTnc lipid IVA biosynthesis Lipopolysaccharide biosynthesis organophosphate metabolic process carbohydrate derivative metabolic process protein N-glycosylation (eukaryotic, high mannose) tubulin complex assembly cullin deneddylation | details |
| TreatCFM000233 | Ubiquitin_Proteasome_system, DUB: JAMM cullin deneddylation COP9 signalosome carbohydrate transport | details |
| TreatCFM000245 | details | |
| TreatCFM000264 | Protein_kinases_phosphatases, PPC:4.1.4: MAP2K defense response, incompatible interaction activation of MAPK activity MAP kinase kinase activity MAP kinase activity MAPK cascade MAPK signaling pathway - plant | details |
| TreatCFM000269 | intracellular COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM cullin deneddylation GTP binding small GTPase mediated signal transduction intracellular protein transport | details |
| TreatCFM000272 | xyloglucan biosynthetic process endomembrane system organization cellular response to gravity fucose biosynthetic process | details |
| TreatCFM000279 | Ubiquitin_Proteasome_system, DUB: JAMM Golgi vesicle budding phospholipid translocation Proteasome phospholipid-translocating ATPase activity proteasome-mediated ubiquitin-dependent protein catabolic process proteasome complex | details |
| TreatCFM000280 | defense response, incompatible interaction activation of MAPK activity lipid transporter activity MAP kinase kinase activity MAP kinase activity Protein_kinases_phosphatases, PPC:4.1.4: MAP2K lipid transport MAPK cascade Lysosome adhesion to carbohydrates, Carbohydrate-Binding Modules: CBM57 Protein_kinases_phosphatases, PPC:1.2.2: Receptor Like Cytoplasmic Kinase VII MAPK signaling pathway - plant | details |
| TreatCFM000284 | second spliceosomal transesterification activity generation of catalytic spliceosome for second transesterification step nuclear retention of unspliced pre-mRNA at the site of transcription Ubiquitin_Proteasome_system, DUB: JAMM U2-type post-spliceosomal complex U5 snRNP proteasome complex U4/U6 x U5 tri-snRNP complex proteasome-mediated ubiquitin-dependent protein catabolic process Proteasome Spliceosome | details |
| TreatCFM000285 | Ubiquitin_Proteasome_system, DUB: JAMM precatalytic spliceosome proteasome complex response to salt stress proteasome-mediated ubiquitin-dependent protein catabolic process Proteasome Spliceosome | details |
| TreatCFM000307 | details | |
| TreatCFM000317 | cytoplasmic, membrane-bounded vesicle | details |
| TreatCFM000331 | Protein_kinases_phosphatases, PPC:4.1.4: MAP2K defense response, incompatible interaction activation of MAPK activity MAP kinase kinase activity MAP kinase activity MAPK cascade MAPK signaling pathway - plant | details |
| TreatCFM000332 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds nitrogen compound metabolic process transferase activity, transferring acyl groups plastid | details |
| TreatCFM000349 | benzoyl-CoA biosynthesis formation of glycosidic bonds, GlycosylTransferases: GTnc Transcription_related, Transcription factor: BES1 Transcription_related, Transcription regulator: LIM Ubiquitin_Proteasome_system, DUB: JAMM glycoprotein 2-beta-D-xylosyltransferase activity fatty acid β-oxidation II (peroxisome) transcription factor activity, sequence-specific DNA binding transcription regulatory region DNA binding benzoate biosynthesis I (CoA-dependent, β-oxidative) protein N-linked glycosylation formation of translation preinitiation complex regulation of transcription, DNA-templated carbohydrate transport regulation of translational initiation brassinosteroid mediated signaling pathway | details |
| TreatCFM000351 | lipid transporter activity lipid transport Lysosome | details |
| TreatCFM000368 | COP9 signalosome cullin deneddylation Ubiquitin_Proteasome_system, DUB: JAMM | details |
| TreatCFM000385 | xyloglucan biosynthetic process endomembrane system organization fucose biosynthetic process | details |
| TreatCFM000390 | Ubiquitin_Proteasome_system, DUB: JAMM L-phenylalanine biosynthesis II L-phenylalanine biosynthesis III (cytosolic, plants) prephenate dehydratase activity arogenate dehydratase activity L-phenylalanine biosynthetic process oxalate metabolic process oxalate decarboxylase activity nutrient reservoir activity manganese ion binding carbohydrate transport amino acid binding proteasome-mediated ubiquitin-dependent protein catabolic process Proteasome Biosynthesis of amino acids | details |
| TreatCFM000403 | Ubiquitin_Proteasome_system, DUB: JAMM proteasome complex Proteasome proteasome-mediated ubiquitin-dependent protein catabolic process | details |
| TreatCFM000416 | Ubiquitin_Proteasome_system, DUB: JAMM proteasome complex Proteasome proteasome-mediated ubiquitin-dependent protein catabolic process | details |
| TreatCFM000423 | Ubiquitin_Proteasome_system, DUB: JAMM proteasome complex Proteasome nucleic acid metabolic process cellular macromolecule metabolic process proteasome-mediated ubiquitin-dependent protein catabolic process | details |
| TreatCFM000430 | Ubiquitin_Proteasome_system, DUB: JAMM Proteasome chloroplast accumulation movement proteasome complex microtubule proteasome-mediated ubiquitin-dependent protein catabolic process microtubule-based movement | details |
| TreatCFM000434 | ADP dimethylallyltransferase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ATP dimethylallyltransferase activity | details |
| TreatCFM000442 | cullin deneddylation Ubiquitin_Proteasome_system, DUB: JAMM COP9 signalosome Phenylpropanoid biosynthesis intracellular part ATP-dependent helicase activity coenzyme binding | details |
| TreatCFM000453 | Ubiquitin_Proteasome_system, DUB: JAMM proteasome complex proteasome-mediated ubiquitin-dependent protein catabolic process Proteasome Sesquiterpenoid and triterpenoid biosynthesis | details |
| TreatCFM000483 | formation of glycosidic bonds, GlycosylTransferases: GTnc protein N-glycosylation (eukaryotic, high mannose) N-Glycan biosynthesis transferase activity, transferring hexosyl groups | details |
| TreatCFM000484 | details | |
| TreatCFM000510 | pyrimidine ribonucleosides salvage I cullin deneddylation pyrimidine nucleoside salvage pyrimidine nucleobase metabolic process DNA integration Ubiquitin_Proteasome_system, DUB: JAMM COP9 signalosome uridine kinase activity Transcription_related, Transcription factor: B3 | details |
| TreatCFM000518 | alkaloid biosynthetic process nitrogen compound metabolic process ajmaline and sarpagine biosynthesis vomilenine glucosyltransferase activity strictosidine beta-glucosidase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds raucaffricine beta-glucosidase activity phospholipid binding | details |
| TreatCFM000564 | PRPP biosynthesis I xylogalacturonan biosynthesis formation of glycosidic bonds, GlycosylTransferases: GTnc nucleoside metabolic process nucleotide biosynthetic process ribose phosphate diphosphokinase activity phospholipid binding translational initiation response to salt stress Spliceosome precatalytic spliceosome | details |
| TreatCFM000574 | cullin deneddylation COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM Transcription_related, Transcription factor: B3 Transcription_related, Transcription factor: WRKY | details |
| TreatCFM000600 | cullin deneddylation COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM | details |
| TreatCFM000601 | cullin deneddylation COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM | details |
| TreatCFM000607 | cullin deneddylation COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM | details |
| TreatCFM000608 | COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM cullin deneddylation DNA integration | details |
| TreatCFM000612 | Ubiquitin_Proteasome_system, DUB: JAMM Proteasome proteasome complex proteasome-mediated ubiquitin-dependent protein catabolic process | details |
| TreatCFM000619 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds nitrogen compound metabolic process transferase activity, transferring acyl groups plastid | details |
| TreatCFM000630 | Ubiquitin_Proteasome_system, DUB: JAMM cullin deneddylation COP9 signalosome small GTPase mediated signal transduction GTP binding | details |
| TreatCFM000631 | COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM cullin deneddylation DNA integration | details |
| TreatCFM000675 | adhesion to carbohydrates, Carbohydrate-Binding Modules: CBM57 hydrolysis and/or rearrangement of glycosidic bonds, Glycoside Hydrolases: GHnc Protein_kinases_phosphatases, PPC:4.1.4: MAP2K endomembrane system organization fucose biosynthetic process xyloglucan biosynthetic process defense response, incompatible interaction activation of MAPK activity MAP kinase kinase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds cell wall macromolecule catabolic process | details |
| TreatCFM000686 | integral component of plasma membrane Smc5-Smc6 complex Ubiquitin_Proteasome_system, DUB: JAMM Proteasome proteasome complex cellular water homeostasis calcium ion transmembrane transport single-organism transport resolution of recombination intermediates double-strand break repair via homologous recombination ion transmembrane transport water channel activity calcium-transporting ATPase activity glycerol channel activity Transcription_related, Transcription factor: bHLH proteasome-mediated ubiquitin-dependent protein catabolic process calmodulin binding | details |
| TreatCFM000715 | Ubiquitin_Proteasome_system, DUB: JAMM cullin deneddylation COP9 signalosome proteasome complex Proteasome proteasome-mediated ubiquitin-dependent protein catabolic process | details |
| TreatCFM000725 | Protein_kinases_phosphatases, PPC:4.1.4: MAP2K defense response, incompatible interaction activation of MAPK activity MAP kinase kinase activity MAP kinase activity MAPK cascade MAPK signaling pathway - plant | details |
| TreatCFM000741 | proteasome complex Ubiquitin_Proteasome_system, DUB: JAMM Proteasome proteasome-mediated ubiquitin-dependent protein catabolic process Transcription_related, Transcription factor: ERF | details |
| TreatCFM000750 | Protein_kinases_phosphatases, PPC:4.1.4: MAP2K activation of MAPK activity defense response, incompatible interaction MAP kinase kinase activity MAP kinase activity MAPK cascade MAPK signaling pathway - plant | details |
| TreatCFM000764 | Protein_kinases_phosphatases, PPC:4.1.4: MAP2K activation of MAPK activity defense response, incompatible interaction MAP kinase kinase activity | details |
| TreatCFM000765 | cytoplasmic, membrane-bounded vesicle | details |
| TreatCFM000774 | COP9 signalosome cullin deneddylation Ubiquitin_Proteasome_system, DUB: JAMM | details |
| TreatCFM000786 | details | |
| TreatCFM000794 | Protein_kinases_phosphatases, PPC:4.1.4: MAP2K defense response, incompatible interaction activation of MAPK activity MAP kinase kinase activity MAP kinase activity MAPK cascade MAPK signaling pathway - plant | details |
| TreatCFM000799 | Ubiquitin_Proteasome_system, DUB: JAMM Proteasome proteasome complex proteasome-mediated ubiquitin-dependent protein catabolic process intracellular part | details |
| TreatCFM000829 | Ubiquitin_Proteasome_system, DUB: JAMM cullin deneddylation COP9 signalosome carbohydrate transport | details |
| TreatCFM000835 | details | |
| TreatCFM000843 | Ubiquitin_Proteasome_system, DUB: JAMM negative regulation of innate immune response petal formation negative regulation of cell proliferation mRNA polyadenylation leaf development proteasome complex mRNA surveillance pathway Proteasome polynucleotide adenylyltransferase activity proteasome-mediated ubiquitin-dependent protein catabolic process | details |
| TreatCFM000859 | coenzyme A biosynthesis I Ubiquitin_Proteasome_system, DUB: JAMM cullin deneddylation COP9 signalosome small ribosomal subunit | details |
| TreatCFM000869 | fucosyltransferase activity Various types of N-glycan biosynthesis formation of glycosidic bonds, GlycosylTransferases: GTnc Lewis a epitope biosynthetic process fucosylation Ubiquitin_Proteasome_system, DUB: JAMM COP9 signalosome Golgi cisterna membrane cullin deneddylation protein glycosylation | details |
| TreatCFM000870 | COP9 signalosome cullin deneddylation Ubiquitin_Proteasome_system, DUB: JAMM ubiquitin-protein transferase activity Ubiquitin_Proteasome_system, E3: U-box protein ubiquitination | details |
| TreatCFM000876 | cullin deneddylation COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM | details |
| TreatCFM000923 | cullin deneddylation COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM | details |
| TreatCFM000964 | cullin deneddylation COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM Phenylpropanoid biosynthesis coenzyme binding | details |
| TreatCFM000969 | cytoplasmic, membrane-bounded vesicle | details |
| TreatCFM000978 | proteasome complex Ubiquitin_Proteasome_system, DUB: JAMM Proteasome Transcription_related, Transcription regulator: PHD proteasome-mediated ubiquitin-dependent protein catabolic process | details |
| TreatCFM000980 | proteasome complex RNA-dependent DNA biosynthetic process RNA-directed DNA polymerase activity Ubiquitin_Proteasome_system, DUB: JAMM Proteasome DNA integration DNA recombination Transcription_related, Transcription factor: bHLH proteasome-mediated ubiquitin-dependent protein catabolic process | details |
| TreatCFM000981 | Ubiquitin_Proteasome_system, DUB: JAMM Proteasome proteasome complex intracellular part response to stimulus regulation of catalytic activity regulation of cellular process proteasome-mediated ubiquitin-dependent protein catabolic process | details |
| TreatCFM001014 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds nitrogen compound metabolic process transferase activity, transferring acyl groups plastid | details |
| TreatCFM001037 | vacuole | details |
| TreatCFM001067 | cullin deneddylation COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM | details |
| TreatCFM001069 | cullin deneddylation COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM Transcription_related, Transcription factor: B3 catalytic activity | details |
| TreatCFM001076 | mitotic spindle assembly checkpoint ATP synthesis coupled electron transport Transcription_related, Transcription factor: bZIP NADH dehydrogenase (ubiquinone) activity mitochondrion | details |
| TreatCFM001084 | cullin deneddylation COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM | details |
| TreatCFM001102 | cullin deneddylation COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM | details |
| TreatCFM001204 | 1,3-β-D-glucan biosynthesis Ubiquitin_Proteasome_system, DUB: JAMM COP9 signalosome spliceosomal complex 1,3-beta-D-glucan synthase complex ubiquitin ligase complex positive regulation of proteasomal ubiquitin-dependent protein catabolic process cullin deneddylation (1->3)-beta-D-glucan biosynthetic process ubiquitin conjugating enzyme binding 1,3-beta-D-glucan synthase activity | details |
| TreatCFM001206 | Ubiquitin_Proteasome_system, DUB: JAMM cullin deneddylation COP9 signalosome nitrogen compound metabolic process hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Phenylpropanoid biosynthesis plastid coenzyme binding transferase activity, transferring acyl groups | details |
| TreatCFM001221 | Ubiquitin_Proteasome_system, DUB: JAMM cullin deneddylation COP9 signalosome carbohydrate transport | details |
| TreatCFM001222 | intracellular protein transport | details |
| TreatCFM001234 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds nitrogen compound metabolic process transferase activity, transferring acyl groups plastid | details |
| TreatCFM001254 | cullin deneddylation COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM | details |
| TreatCFM001265 | details | |
| TreatCFM001329 | cullin deneddylation COP9 signalosome Ubiquitin_Proteasome_system, DUB: JAMM | details |
| TreatCFM001390 | riboflavin synthase activity Ubiquitin_Proteasome_system, DUB: JAMM proteasome complex Riboflavin metabolism Transcription_related, Transcription factor: bZIP Proteasome riboflavin biosynthetic process proteasome-mediated ubiquitin-dependent protein catabolic process | details |
| TreatCFM001637 | Ubiquitin_Proteasome_system, DUB: JAMM rosmarinic acid biosynthesis I rosmarinic acid biosynthesis II 4-hydroxybenzoate biosynthesis I (eukaryotes) rRNA primary transcript binding oligosaccharyltransferase complex COP9 signalosome maturation of LSU-rRNA maturation of 5.8S rRNA protein N-linked glycosylation cullin deneddylation oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ribosomal large subunit assembly NAD binding preribosome, large subunit precursor N-Glycan biosynthesis embryo development ending in seed dormancy | details |
| TreatCFM001704 | Ubiquitin_Proteasome_system, DUB: JAMM hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds RNA polymerase II transcription factor activity, sequence-specific DNA binding cullin deneddylation ribosomal large subunit assembly nitrogen compound metabolic process COP9 signalosome nucleoplasm transferase activity, transferring acyl groups | details |
| TreatCFM001804 | Ubiquitin_Proteasome_system, DUB: JAMM Transcription_related, Transcription regulator: LIM formation of translation preinitiation complex regulation of translational initiation eukaryotic 48S preinitiation complex eukaryotic translation initiation factor 3 complex proteasome complex eukaryotic 43S preinitiation complex proteasome-mediated ubiquitin-dependent protein catabolic process Homologous recombination Proteasome RNA transport | details |
Expression profiles
 Show details about module gene expression profiling |